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News

Congratulations to Dr. Tingwei Mu
July 1, 2019

Dr. Mu has been promoted to Associate Professor, effective July 1, 2019.

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DPB Annual Baseball Outing
Aug. 23, 2019 7:10 p.m.

The Department will host its annual Cleveland Indians baseball outing on Friday, August 23, 2019.

The Indians will play the Kansas City Royals at 7:10 p.m. at Progressive Field in downtown Cleveland.

We host the baseball outing at the beginning of each new academic year to welcome our new graduate students and to provide an enjoyable evening for returning students, faculty, and staff. Tickets are complimentary for our students and department associates, and the Terrace Club has again been reserved this year for our attendees.

Image: http://a.espncdn.com/photo/2017/0918/r260637

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Department 18th Annual Retreat
Sept. 19, 2019 - Sept. 20, 2019

The Department of Physiology and Biophysics will hold its18th annual retreat at the Kalahari Resort in Sandusky, OH on Thursday and Friday, September 19 and 20.

Facutly, postdocs, Ph.D. and M.S. graduate students, and research staff will attend.

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2019 Recknagel Symposium
Sept. 19, 2019

The Department of Physiology and Biophysics annual Recknagel Symposium will take place on Thursday, September 19, 2019 during the department’s 18th annual retreat.

Five of the Department’s second year doctoral students, José Diaz-Aponte, Benjamin Dumm, Katherine Horan, Ryan Lingerak, and Ling Xu will present from their first year research laboratory rotations. Mr. Diaz-Aponte is in the lab of Dr. George Dubyak; Mr. Dumm and Ms. Xu are in the lab of Dr. Wïtold Surewicz; Ms. Horan is in the lab of Dr. Xin Qi; and Mr. Lingerak is in the lab of Dr. Bing-Cheng Wang.

The department established the annual Recknagel Symposium in memory of Professor Richard Recknagel, who was Chair of the Department of Physiology from 1976 until 1986 and an admired thinker and investigator who took a keen interest in mentoring young students and faculty.

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Dr. Leslie Leinwand of the University of Colorado to give 5th Annual Matthew N. Levy Lecture
Oct. 31, 2019

 

Leslie Leinwand, Ph.D., F.A.H.A., Distinguished Professor in the Department of Molecular, Cellular & Developmental Biology (MCDB) and the Chief Scientific Officer of the BioFrontiers Institute at the University of Colorado, will give the 5th Annual Department of Physiology and Biophysics Matthew N. Levy Lecture on Thursday, October 31, 2019 (time TBD).

The title of Dr. Leinwand's lecture will be “Myosin myopathies: mechanisms of pathogenesis and paths to therapeutics.”

The late Dr. Matthew Levy was a gifted, dedicated teacher and scientist who influenced countless students, conducted groundbreaking research on heart function and its relationship to the autonomic nervous system, and who co-authored one of the most influential texts on physiology. Each autumn, beginning with a daylong symposium in 2014, the Department honors the memory of Dr. Levy and his accomplishments.

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Recent News


DPB 2019 Annual Summer Picnic
July 26, 2019 3 p.m. - 7 p.m.

The Department hosted its annual summer picnic on Friday, July 26, 2019 from 3:00 - 7:00 p.m. at the University's Squire Vallevue Farm in Hunting Valley.

Department faculty, associates, and students and their families and significant others attended, as well as interns who have joined us for the summer.

Group activities included softball and volleyball.

A barbecue of chicken and ribs and hamburgers and hot dogs was provided by Bon Appétit.

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Post-Bacc Application Deadline
July 22, 2019

July 22th, 2019 is the extended deadline for submitting applications for the MS in Medical Physiology Program (Post-Bacc Program).  The admissions committee will review your application once it is complete and all application materials are received.  If you have any questions, please contact Dr. Nosek (thomas.nosek@case.edu, 216-368-3242). Contact us if you need assistance.

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Open House for Post-Bacc Medical Physiology Program
June 22, 2019 10 a.m. - 4 p.m.

The Department will hosted an Open House for all students, parents, and undergraduate advisors interested in learning more about the M.S. in Medical Physiology Post-Bacc program on Saturday, June 22, 2019.  A full day of activities was held.

For more information:  https://physiology.case.edu/education/department-open-house/

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Congratulations to Dr. John Li
June 17, 2019 2 p.m.

John Li, a Ph.D. candidate in the Medical Scientist Training Program in the lab of and mentored by Dr. Julian Stelzer, publicly defended his doctoral dissertation on Monday, June 17, 2019 at 2:00 p.m. in SOM E-501.

The title of John's dissertation is "Examining the efficacy of MyBPC based therapies in mouse models of cardiomyopathies."

A reception was held in the new Dr. Li's honor in the Department's 5th floor bridge area following the defense.

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Congratulations to Dr. Di Hu
May 21, 2019 2 p.m.

Di Hu, a Ph.D. candidate mentored by and in the lab of Dr. Xin Qi, publicly defended his doctoral disseration on Tuesday, May 21, 2019 at 2:00 p.m. in SOM E-501.

The title of Dr. Hu's dissertation is “Targeting Mitochondria as a Potential Therapeutic Strategy for Neurodegenerative Disease.”

A reception in Di's honor was held immediately following the defense.

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Congratulations to Dr. Jie Yang
May 2, 2019 10 a.m.

Jie Yang, mentored by and in the lab of Dr. Sam Xiao, publicly defended his doctoral dissertation on Tuesday, May 2, 2019 at 10:00 a.m. in SOM E-501.

The title of Jie's dissertation is “Structure, function, and regulation of inflammatory caspases in inflammation and pyroptosis.”

A festive brunch reception for the newly minted Ph.D. was held in the department's 5th floor bridge area following the defense.

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Aerospace Physiology Symposium seminar - Jay Dean, Ph.D.
April 30, 2019 noon

As part of the Department of Physiology and Biophysics Inaugural Symposium for the Center for Aerospace Physiology, Dr. Jay Dean presented a seminar entitled "Winning the physiological air war of 1939-1945: the history of aero medical research and practices in America during WW2" on Tuesday, April 30 at 12:00 noon in SOM E-501.

Dr. Dean is a Professor in the Department of Molecular Pharmacology and Physiology and an Adjunct Professor in the Department of Military and Emergency Medicine at the College of Medicine at the University of South Florida in Tampa.

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Inaugural Symposium for the Center for Aerospace Physiology
April 29, 2019 - April 30, 2019

We are pleased to announce the Inaugural Symposium for the Center for Aerospace Physiology to be held at Case Western Reserve University on April 29-30, 2019.  The Center for Aerospace Physiology is housed within the Department of Physiology & Biophysics, at the School of Medicine. Our team of multidisciplinary scientists collaborate closely with flight surgeons and aerospace physiologists from NASA, the USAF and USN to develop new strategies enabling humans to live and thrive within austere environments on earth, the upper atmosphere, and beyond.

For more information: https://physiology.case.edu/events/symposia-and-endowed-lectures/center-for-aerospace-physiology-symposium/ 

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Congratulations to Drs. Kui Xu, Joseph LaManna, and Walter Boron...
April 15, 2019

 

…on the publication of “Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcomein Two Models of CNS Injury” in Neuroscience 404, 484-498  (04-15-2019)

https://www.sciencedirect.com/science/article/pii/S0306452219300545

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Open House for Post-Bacc Medical Physiology Program
April 13, 2019 10 a.m. - 4 p.m.

The Department will host an Open House for all students, parents, and undergraduate advisors interested in learning more about the M.S. in Medical Physiology Post-Bacc program on Saturday, April 13, 2019.  A full day of activities is scheduled.

For more information:  https://physiology.case.edu/education/department-open-house/

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Congratulations to Dr. Yvonne Gicheru
March 29, 2019 2 p.m.

Yvonne Gicheru, a Ph.D. candidate mentored by and in the lab of Dr. Sudha Chakrapani, publicly defended her doctoral dissertation on Friday, March 29, 2019 at 2:00 p.m. in SOM E-501.

Yvonne's dissertation is entitled "Structural basis for functional modulation of pentameric ligand-gated ion channels."

A reception was held in Yvonne's honor immediately after the defense in the department's 5th floor bridge area.

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Congratulations to Sahej Bindra
March 26, 2019

Sahej Bindra, a senior at the Hathaway Brown School and a student intern in the lab of Dr. Joseph LaManna, was awarded fourth place in the research paper competition at the 56th Ohio Junior Science and Humanities Symposium held at Bowling Green State University, March 13-15, 2019.

The title of Sahej's paper is “Environmental enrichment improved cognitive performance in mice under normoxia and hypoxia.”

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7th Annual Ulrich Hopfer Lecture
March 18, 2019 4 p.m.

Alicia A. McDonough, Ph.D., F.A.H.A., a Professor of Integrative Anatomical Science at the University of Southern California Keck School of Medicine, gave the 7th Annual Ulrich Hopfer Lecture on Monday, March 18, 2019 at 4:00 in SOM E-501, hosted by Dr. Walter Boron and Dr. Ulrich Hopfer.

The title of Dr. McDonough's lecture was "Maintaining Balance under Pressure: renal adaptations to angiotensin II hypertension in females and males."

Dr. McDonough also met with facutly members during her visit and a reception in her honor was held in the Department 5th floor lobby prior to her lecture.

The Department of Physiology and Biophysics hosts the Hopfer lecture each March to honor Professor Emeritus Ulrich Hopfer, M.D., Ph.D.

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Congratulations to Dr. Kate Fu
March 15, 2019 4 p.m.

Kate (Yanlin) Fu, a Ph.D. candidate mentored by and in the lab of Dr. Tingwei Mu, publicly defended her doctoral dissertation on Friday, March 15, 2019 at 4:00 p.m. in SOM E-501.

The title of Kate's dissertation is "Proteostasis maintenance of  γ-aminobutyric acid type A receptors (GABAARs)"

A festive reception in honor of the newly minted Ph.D. followed the defense in the department's 5th floor bridge area.

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Archived News


Congratulations to Dr. Yuanyuan Zhao
Feb. 21, 2019

Dr. Zhao, a postdoctoral scholar in the lab of Dr. Xin Qi, has had the paper “ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentationwith bioenergetics defects” accepted for publication by Nature Communications.

Zhao YY, Sun XY, Hu D, Prosdoci D, Jain M, Hoppel C, Ramachandran R and Qi X.

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Congratulations to Di Hu
Feb. 6, 2019

Di Hu, a Ph.D. candidate in the lab of Dr. Xin Qi, has had the paper “Alpha-Synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity” accepted as first author for publication by Acta Neuropathologica.

Authors: Di Hu, Xiaoyan Sun, Xudong Liao, Xinwen Zhang, Sara Zarabi, Aaron Schimmer, Yuning Hong, Christopher Ford,  Yu Luo and Xin Qi.

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Welcome to Dr. Eric Gibbs
Jan. 23, 2019

Eric Gibbs, Ph.D. has joined the lab of Dr. Sudha Chakrapani as a Postdoctoral Scholar, effective January 23, 2019.

Eric was recently awarded his doctorate by Duke University.

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Welcome to Dr. Nami Tajima
Jan. 2, 2019

The Department welcomes Dr. Nami Tajima as a new faculty member, effective January 2, 2019.

Prior to joining the department Dr. Tajima was a postdoctoral fellow in the lab of Dr. Hiro Furukawa at the Cold Spring Harbor Laboratory in New York.

Dr. Tajima was selected as a Mount Sinai Scholar in October 2018.

 

 

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DPB Annual Holiday Party
Dec. 15, 2018 6:30 p.m. - 10:30 p.m.

The Department hosted its annual holiday party on Saturday, December 15 from 6:30-10:30 p.m. at the Western Reserve Historical Society in University Circle.

Catering was by A Taste of Excellence and a string ensemble provided seasonal music.

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Congratulations to Qiuye Li and Dr. Xiangzhu Xiao...
Nov. 30, 2018

...on the publication of the manuscript, "Structural attributes of mammalian prion infectivity: Insights from studies with synthetic prions" in the Journal of Biological Chemistry.

Quiye Li (l), is a Ph.D. candidate and Xiangzhu Xiao, Ph.D. (r) is a Research Associate, both in the lab of Wïtold Surewicz, Ph.D., the Robert F. Bennett, M.D. Professor in the Department of Physiology and Biophysics.

The paper was selected as a JBC Editor's Pick and was accompanied by the profile of the first author, Qiuye Li.

J Biol Chem 293, 18494-18503 (2018)

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Congratulations to Dr. Soumili Chatterjee
Nov. 20, 2018 9 a.m.

Soumili Chatterjee, a Ph.D. candidate in the lab of and mentored by Dr. Sudha Chakrapani, publicly defended her doctoral dissertation on Tuesday, November 20, 2018 at 9:00 a.m. in SOM E-501.

The title of Soumili's dissertation is “Understanding the structural basis of slow inactivation in voltage-gated sodium channel."

A brunch reception in Soumili's honor was held in the 5th floor bridge area following the defense.

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DPB FRONTIERS IN BIOLOGICAL SCIENCES LECTURE
Oct. 24, 2018 4 p.m.

A. Radu Aricescu, Ph.D., a Medical Research Council (MRC) Senior Research Fellow in the Laboratory of Molecular Biology’s Neurobiology Division at the University of Cambridge, presented a School of Medicine Frontiers in Biological Sciences Lecture on Wednesday, October 24, 2018 at 4:00 p.m. in SOM E-501, hosted by Dr. Sudha Chakrapani and the Department . The title of Dr. Aricescu's lecture was "Human GABAA Receptor Structures and Signaling Mechanisms."

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Congratulations to Michael Babinchak
Oct. 2, 2018

Michael Babinchak, an M.D./Ph.D. candidate in the Medical Scientist Training Program in the lab of Dr. Wïtold Surewicz, has been awarded an F30 grant from the National Aging Institute for the project "Pathological aggregation of TDP-43 in age-related neurodegenerative diseases."

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Welcome to Dr. Xinghong Dai
Oct. 1, 2018

Xinghong Dai, Ph.D. joins the faculty of the Department of Physiology and Biophysics, effective October 1, 2018.

Dr. Dai was previously a postdoctoral scholar in the lab of Dr. Ren Sun in the Department of Molecular and Medical Pharmacology at the University of California – Los Angeles.

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2018 Annual Department Retreat
Sept. 21, 2018

The Department held its annual retreat on Friday, September 21, 2018 from 7:30 a.m. - 5:00 p.m. at the Huntington Convention Center in downtown Cleveland.

Our annual Recknagel Symposium will also took place during the retreat. See the entry below for details.

 

 

Image: booking.com

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2018 Annual Recknagel Symposium
Sept. 21, 2018

The Department of Physiology and Biophysics held its annual Recknagel Symposium at the annual department retreat on Friday, September 21, 2018 at the Huntington Cleveland Convention Center.

Three of the Department’s second year doctoral students, Sara Taki, Paulina Getsy and Raza Haider presented from their first year research laboratory rotations. Raza Haizer, a member of the lab of Dr. Witold Surewicz, won the competition with his presentation, "Characterizing the aggregation propensity of pathologically-relevant TDP-43 ALS mutants."

The department established the annual Recknagel Symposium in memory of Professor Richard Recknagel, who was Chair of the Department of Physiology from 1976 until 1986 and an admired thinker and investigator who took a keen interest in mentoring young students and faculty.

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Welcome to Hannah Schwab
Sept. 10, 2018

The Department welcomes Hannah Schwab, who has joined the lab of Dr. Ardeschir Vahedi-Faridi as a Research Assistant 1, effective September 10, 2018.

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Dr. Joseph Hill of UT Southwestern gives 4th Annual Levy Lecture
Sept. 7, 2018 1:30 p.m.

Joseph A. Hill, M.D., Ph.D., a Professor of Internal Medicine and Molecular Biology, the James T. Willerson, M.D. Distinguished Chair in Cardiovascular Diseases, the Frank M. Ryburn, Jr. Chair in Heart Research, the Chief of the Division of Cardiology, and the Director of the Harry S. Moss Heart Center at the University of Texas Southwestern Medical Center in Dallas, presented the Department of Physiology and Biophysics 4th Annual Matthew N. Levy Lecture on Friday, September 7, 2018 at 1:30 p.m. in SOM E-501.

Dr. Hill's lecture was entitled “Heart Failure: Two Inflammatory Tales.”

The late Dr. Matthew Levy was a gifted, dedicated teacher and scientist who influenced countless students, conducted groundbreaking research on heart function and its relationship to the autonomic nervous system, and who co-authored one of the most influential texts on physiology. Each autumn, beginning with a daylong symposium in 2014, the Department honors the memory of Dr. Levy and his accomplishments.

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Congratulations to Dr. Sudha Chakrapani
Sept. 6, 2018

Dr. Chakrapani, an associate professor in the Department of Physiology and Biophysics, has received an NIH S10 High-End Instrumentation (HEI) grant to purchase a Pulsed-EPR spectrometer.

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2018 Annual Department Baseball Outing
Aug. 31, 2018 7:10 p.m.

The Department hosted its annual baseball outing on Friday, August 31, 2018 at 7:10 p.m. at Progressive Field in downtown Cleveland.

The Cleveland Indians shut out the Tampa Bay Rays 3 - 0.

We host the baseball outing at the beginning of each new academic year to welcome our new students and to provide an enjoyable evening for returning students, faculty, and staff. Tickets are complimentary for our students and department associates, and seating this year was in the Terrace Club.     

Image: Annie O'Neill

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Congratulations to Sandip Basak and Yvonne Gicheru
Aug. 30, 2018

Yvonne Gicheru (l) and Dr. Sandip Basak (c), a Ph.D. candidate and a postdoctoral fellow, respectively, in the lab of Dr. Sudha Chakrapani, have had the paper, "Cryo-EM reveals two distinct serotonin-bound states of the full-length 5-HT3A receptor" accepted for publication in Nature.

Sandip Basak, Yvonne Gicheru, Shanlin Rao, Mark Sansom, and Sudha Chakrapani

 

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Welcome 2018 M.S.M.P. Entering Class
Aug. 23, 2018

The Department welcomes 174 new students to its Master of Science in Medical Physiology program.

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Welcome to Eva Gilker
Aug. 13, 2018

Eva Gilker has joined the lab of Dr. Walter Boron as a Research Assistant II, effective August 13, 2018.

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Congratulations to Dr. Agustin Gonzalez Vicente and the Garvin and Hopfer Labs
Aug. 1, 2018

Agustin Gonzalez Vicente, Ph.D., in collaboration with the labs of Dr. Jeffrey Garvin and Dr. Ulrich Hopfer, has had published as first author the paper, "Transcriptome signature for dietary fructose-specific changes in rat renal cortex: A quantitative approach to physiological relevance."

 

 

Gonzalez-Vicente A, Garvin JL, Hopfer U.

PLoS One. 2018 Aug 1;13(8):e0201293.doi:10.1371/journal.pone.0201293. eCollection 2018.

PMID:30067804 [PubMed - in process]

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Congratulations to the Lab of Dr. Julian Stelzer...
Aug. 1, 2018

...on the acceptance of the paper, "Impact of the myosin modulator mavacamten on force generation and cross-bridge behavior in a murine model of hypercontractility," by the Journal of the American Heart Association.

Ranganath Mamidi, Ph.D.; Jiayang Li, B.S; Chang Yoon Doh, B.S; Sujeet Verma, Ph.D. (not pictured); Julian E. Stelzer, Ph.D.

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Annual Department Summer Picnic
July 26, 2018 3 p.m. - 7 p.m.

The Department hosted its 2018 annual summer picnic on Thursday, July 26 from 3:00 - 7:00 p.m. at the Cleveland Botanical Garden in University Circle.

All Department students, associates and their families and significant others were invited to attend.

Catering was by Bon Appétit.

 

Image: inacents.com

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Post-Bacc Application Deadline
July 16, 2018

July 16th, 2018 at midnight is the official deadline for submitting applications for the MS in Medical Physiology Program (Post-Bacc Program).  The admissions committee will review your application once it is complete and all application materials are received.  If you have any questions, please contact Dr. Nosek (thomas.nosek@case.edu, 216-368-3242). Contact us if you need assistance.

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Welcome to Summer Visiting Medical Students
July 13, 2018

The Department welcomes summer visiting medical students from Yeditepe University in Istanbul.

Burak Ekincikli (l), a third year student of the Faculty of Medicine, is working in the lab of Dr. Walter Boron.

Berfin Ece Akbulut (r), a fourth year student of the Faculty of Medicine, is working in the lab of Dr. Matthias Buck.

Burak and Berfin will both be in the Department until August.

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Congratulations to Soumili Chatterjee
July 13, 2018

Soumili Chatterjee, a Ph.D. candidate in the lab of Dr. Sudha Chakrapani, has had the paper, "The Voltage-Gated Sodium Channel Pore exhibits Conformational Flexibility during Slow Inactivation" accepted for publication by the Journal of General Physiology*.

Chatterjee, S., Vyas, R., Chalamalasetti, S., Sahu, I., Clatot, J., Lorigan, GA., Deschêne I., and Chakrapani, S.

*JGP will feature a Commentary to highlight this work.

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Welcome to Dr. Meng Wang
July 2, 2018

Meng Wang, Ph.D. has joined the lab of Dr. Tingwei Mu as a postdoctoral scholar, effective July 2, 2018.

Meng received his Ph.D. in molecular biology from China Agricultural University.

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Congratulations to Dr. Rajesh Ramachandran
July 1, 2018

Rajesh Ramachandran, Ph.D. has been promoted to Associate Professor in the Department of Physiology and Biophysics, effective July 1, 2018.

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Dr. Michael Decker joins Department faculty
June 26, 2018

Michael Decker, Ph.D. had joined the faculty of the Department of Physiology and Biophysics as an Associate Professor.

Dr. Decker is a systems physiologist who received his Ph.D. from CWRU, followed by faculty appointments at Emory University and the CDC. His research is focused upon characterizing mechanisms through which hypoxia evokes structural and functional impairments within neural circuits mediating cognition and motor control. His laboratory employs both clinical and laboratory-based techniques                                                                                      ranging from human neuroimaging to immunohistochemistry.

Dr. Decker is currently funded by the NIH and the Dept.of Defense.

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Welcome to Nianxin Yang
June 25, 2018

Nianxin Yang has joined the lab of Dr. Jeff Garvin as a Research Assistant I, effective June 25, 2018.

Nianxin received a bachelor's degree from Case in May of this year and was an intern in Dr. Garvin's lab as an undergraduate.

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Welcome to Faridat Folarin-Amode as a Summer Visiting Medical Student
June 20, 2018

Faridat Folarin-Amode, a second year student at the University of Illinois College of Medicine, is working in the lab of Dr. Matthias Buck as a visiting summer medical student.

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Welcome to Summer 2018 High School Interns
June 15, 2018

Sahej Bindra - Hathaway Brown - LaManna/Decker Lab

Jennifer Wang - Hathaway Brown - Dubyak Lab

Ian Bhatia - Shaker Heights High School - Dubyak Lab

Gabriel Papell - Shaker Heights High School - Boron Lab

Mehmet Yilmaz - Solon High School - Boron Lab

(l to r)

                                                                                Marisa Mohapatra (not pictured) - Hawken - Romani Lab

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Welcome to Summer 2018 High School Interns - Lab of Dr. Rajesh Ramanchandran
June 15, 2018

 

Pranav Viswanathan (l) - Wm. Mason High School (Cincinnati)

Adithya Sreenivas (r) - Aurora High School

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Congratulations to Dr. David Litvin
June 5, 2018 4 p.m.

David Litivin, a Ph.D. candidate mentored by Frank Jacono, M.D., publicly defended his doctoral dissertation at 4:00 p.m. on Tuesday, June 5, 2018 in SOM E-501.

David's dissertation is entitled "Immune-to-Brain Communication Driven by Sterile Lung Injury."

A reception in the new Dr. Litvin's honor was held following the defense at 5:00 p.m. in the Department's fifth floor bridge area.

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Welcome to Dr. Tien-Hao Chen
June 1, 2018

Tien-Hao Chen, Ph.D. has joined the lab of Dr. Wïtold Surewicz as a postdoctoral scholar, effective June 1, 2018.

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Congratulations to Dr. Amrita Samanta
May 31, 2018 4 p.m.

Amrita Samanta, a Ph.D. candidate mentored by Dr. Vera Moiseenkova-Bell, will publicly defended her doctoral dissertation on Thursday, May 31, 2018 at 4:00 p.m. in SOM E-501.

The title of Dr. Samanta's dissertation is "Understanding the Molecular Mechanism of TRP channel activation/inhibition by structural analysis."

A reception in Amrita's honor was held following the defense at 5:00 p.m. in the Department's 5th floor bridge area.

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Congratulations to Jie Yang
May 22, 2018

Jie Yang, a Ph.D candiate in the lab of Dr. Tsan Xiao, had the following paper accepted as first author on May 22, 2018:

"Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor”

Proc. Natl. Acad. Sci. USA [In press] [Available online June 11, 2018]

Jie Yang, Zhonghua Liu, Chuanping Wang, Rui Yang, Joseph K. Rathkey, Otis W. Pinkard, Wuxian Shi, Yinghua Chen, George R. Dubyak, Derek W. Abbott, and Tsan Sam Xiao

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Congratulations to Dr. Peyvand Amini
May 7, 2018 4 p.m.

Peyvand Amini, who was mentored by and a member of the lab of Dr. Sam Mesiano in the Department of Reproductive Biology, publicly defended her doctoral dissertation on Monday, May 7, 2018 at 4:00 p.m. in SOM E-501.

The title of Peyvand's dissertation is "Mechanisms by which progesterone controls human pregnancy and parturition."

A reception in Dr. Amini's honor was held at 5:00 p.m. in the Department's 5th floor bridge area.

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Frontiers in Biological Sciences Lecture
April 18, 2018 4 p.m.

Dr. Walter Boron and the Department of Physiology and Biophysics hosted Dr. Peter Hunter of the University of Auckland for a School of Medicine Frontiers in Biological Sciences Lecture on Wednesday, April 18, 2018 at 4:00 p.m. in SOM E-501.

The title of Dr. Hunter's Frontiers Lecture was “Cardiac research at the Auckland Bioengineering Institute.”

Dr. Hunter is a Distinguished Professor of Engineering Science and the Director of the Auckland Bioengineering Institute at the University of Auckland (New Zealand).

A reception was held in Dr. Hunter's honor at 3:30 p.m. in the Department fifth floor lobby.

In addition, Dr. Hunter also gave a technical talk, “A mathematical physics and computer science framework for reproducible multiscale modelling in physiology”, on Thursday, April 19, 2018 at 4:00 p.m. in SOM E-501.

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Open House for Post-Bacc Medical Physiology Program
April 7, 2018 10 a.m. - 4 p.m.

The Department will hold an Open House for all students, parents, and undergraduate advisors interested in learning more about the MS in Medical Physiology Post-Bacc program on Saturday, April 7, 2018.  A full day of activities is scheduled. Please register here online. A second Open House will be held on Saturday, July 14, shortly before the application deadline.

For more information:  https://physiology.case.edu/education/department-open-house/

To register for the Open House:  https://physiology.case.edu/apply-masters-open-house/

 

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Congratulations to David Litvin
March 27, 2018

David Litvin, a Ph.D. candidate mentored by Frank Jacono, M.D., has had his first paper accepted by Brain, Behavior and Immunity.

The title of David's paper is "Lung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal rats."

(David G Litvin, Thomas E Dick, Corey B Smith, Frank J

                                                                                 Jacono, Brain, Behavior, and Immunity 2018 March 27)

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6TH ANNUAL ULRICH HOPFER LECTURE
March 19, 2018 4 p.m.

 

Mark A. Knepper, M.D., Ph.D. of the National Heart, Lung, and Blood Institute of NIH gave the 6th Annual Ulrich Hopfer Lecture on Monday, March 19, 2018 at 4:00 in SOM E-501, hosted by Dr. Walter Boron and Dr. Ulrich Hopfer.

The title of Dr. Knepper's lecture was “Regulation of Aqp2 gene expression by vasopressin."

Dr. Knepper also met with facutly members during his visit and a reception in his honor was held prior to the lecture in the Department 5th floor lobby.

The Department of Physiology and Biophysics hosts the Hopfer lecture each Spring to honor Professor Emeritus Ulrich Hopfer, M.D., Ph.D.

(Photo: Walter Boron, M.D., Ph.D., Mark Knepper, M.D., Ph.D., Ulrich Hopfer, M.D., Ph.D.)

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Congratulations to Dr. Tingwei Mu
Feb. 16, 2018

Dr. Mu received a 4.0 percentile rating on his NIH RO1 research proposal, “Understanding GABAA receptor protein folding and misfolding.”

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Congratulations to Dr. Sam Chai
Jan. 19, 2018 4 p.m.

Sam Chai, a Ph.D. candidate advised by and in the lab of Dr. Isabelle Deschenes, publicly defended his doctoral dissertation on Friday, January 19, 2018 at 4:00 p.m. in SOM E-501.

Sam's dissertation is entitled "Novel Genetic Modifiers in a Monogenic Cardiac Arrhythmia."

A reception in the new Ph.D.'s honor followed the defense in the Department 5th floor bridge area.

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Congratulations to Dr. Sandip Basak
Jan. 10, 2018

Sandip Basak, Ph.D., a Postdoctoral Fellow in the lab of Dr. Sudha Chakrapani, has had the manuscript "Cryo-EM structure of 5-HT3A receptor in its resting conformation" accepted for publication by Nature Communications.

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Welcome to Dr. Felipe Montecinos
Jan. 2, 2018

Felipe Montecitos, Ph.D. has joined the lab of Dr. Rajesh Ramachandran as a Postdoctoral Scholar, effective January 2, 2018.

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Congratulations to Dr. Sudha Chakrapani
Dec. 13, 2017

Dr. Chakrapani has been appointed to the Editorial Board of the Journal of General Physiology for the term January 1, 2018
through December 31, 2020.

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Congratulations to Dr. Michael Glidden
Dec. 12, 2017 3:30 p.m. - 4:30 p.m.

Michael Glidden (l), an M.D./Ph.D. candidate in the Medical Sciences Training Program, publicly defended his doctoral dissertation on Tuesday, December 12 at 3:00 p.m. in SOM E-501.

The title of Michael's dissertation is "Single-chain insulin analogs as ultra-stable therapeutics."

The new Ph.D. has been advised by Michael Weiss, M.D., Ph.D., M.B.A. (r), who is the Cowan-Blum Professor of Cancer Research and Professor of Biochemistry & Medicine in the Endocrine Division of the Department of Biochemistry.

We wish Michael well as he returns to the M.D. track of the program in the School of Medicine.

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DPB Annual Holiday Party
Dec. 9, 2017 6:30 p.m. - 10:30 p.m.

The Department hosted its annual holiday party on Saturday, December 9 from 6:30-10:30 p.m. at the Cleveland Museum of Natural History in University Circle.

The number of attendess exceeded 300 this year, including faculty, students, staff, and special guests of the department.

A string ensemble provided music and there were two planetarium shows for the attendees.

                                                                                Catering was by Zack Bruell.

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Welcome to Dr. Arvind Kumar
Dec. 1, 2017

Arvind Kumar, Ph.D. has joined the lab of Dr. Sudha Chakrapani as a Postdoctoral Scholar, effective December 1, 2017.

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Congratulations to Dr. Mausita Karmakar...
Nov. 22, 2017

who is one of only three travel grant awardees for the 2018 Keystone Symposium on Cell Death, Inflammation & Adaptation to Tissue Stess to be held at the Beaver Run Resort in Breckenridge, Colorado, January 21-25.

Based on her abstract submission, Dr. Karmakar has also been chosen to give an oral presentation at the symposium.

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Congratulations to Amday Wolde
Nov. 17, 2017

Amday, a second year student in the combined Master's in Medical Physiology/M.B.A. program, received first prize with his team in the Cleveland Clinic Solutions’ mini case competition held in October.

Amday's team took on the challenge of improving the Cleveland Clinic’s Weight Management Program. As a result of the team’s presentation, the Clinic plans to move forward with one of the ideas in the team’s model regarding a wellness program involving cooking.

Source: https://weatherhead.case.edu/news/2017/11/17/students-team-wins-cleveland-clinic-solutions-competition-

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Congratulations to Dr. Xin Qi
Nov. 9, 2017

Dr. Qi has received a one-year Falk Medical Research Trust Catalyst Award for research regarding "Identification of Enhancers of Mitochondrial Function as Candidate Therapeutics of Huntington's Disease,“ effective November 30, 2017

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2017 Department Retreat
Oct. 19, 2017 - Oct. 20, 2017

The Department of Physiology and Biophysics held its annual retreat at the Kalahari Resort in Sandusky, OH on Thursday and Friday, October 19 and 20, 2017.

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Help for Puerto Rico
Oct. 2, 2017 8:30 a.m. - Oct. 6, 2017 5 p.m.

Please bring your items to: Weatherhead Graduate Student Services Office (PBL – 150) Monday, October 2nd through Friday, October 6th, 8:30am – 5:00pm .  Click here Puerto_Rico_Relief_Flyer.pdf for a list of items needed.

For any additional information please contact: Edwin Pacheco (787)-345-1856 (exp199@case.edu)

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3rd Annual Matthew Levy Lecture
Sept. 28, 2017 3 p.m.

The Department hosted the 3rd Annual Matthew N. Levy Lecture on Thursday, September 28, 2017 at 3:00 p.m. in SOM E-501.

The lecture was given by Jeanne Nerbonne, Ph.D., an Alumni Endowed Professor of Molecular Biology and Pharmacology in Medicine and Developmental Biology, the Director of the Center for Cardiovascular Research, and the Co-Director of the Center for the Investigation of Membrane Excitability Diseases at the Washington University School of Medicine in St. Louis.

The title of Dr. Nerbonne's lecture was "Diversity of Cardiac Ion Channel Regulatory Mechanisms.”

A pre-lecture reception for Dr. Nerbonne was held in the Department lobby, and our Chair, Dr. Walter Boron, presented Dr. Nerbonne with an engraved plaque after the lecture to commemorate her presentation.

The late Dr. Matthew Levy was a gifted, dedicated teacher and scientist who influenced countless students, conducted groundbreaking research on heart function and its relationship to the autonomic nervous system, and who co-authored one of the most influential texts on physiology. Each autumn, beginning with a daylong symposium in 2014, the Department honors the memory of Dr. Levy and his accomplishments.

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2017 Recknagel Symposium
Sept. 13, 2017 9 a.m.

The Department of Physiology and Biophysics held its annual Recknagel Symposium on Thursday, September 13, 2017 at 9:00 a.m. in the Department lecture hall.

Two of the Department's second year doctoral students, Sheng Gong (l) and Yutong Shang (r) presented on projects from their first year laboratory rotations. Yutong Shang received the award for the best presentation and Sheng Gong received the award for academic achievement. Sheng is a member of the lab of Dr. Christopher Ford and Yutong is a member of the lab of Dr. Xin Qi.

The Department established the annual Recknagel Symposium in memory of Professor Richard Recknagel, who was Chairman of the Department of Physiology from 1976 to 1986 and an admired thinker and investigator who took a keen interest in mentoring young students and faculty.

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Congratulations to Dr. Stephan Nieuwoudt
Sept. 1, 2017 4 p.m.

Stephan Nieuwoudt, a Ph.D. candidate mentored by and in the lab of Dr. John Kirwan at the Lerner Research Institute of the Cleveland Clinic Foundation, publicly defended his doctoral dissertation on Friday, September 1, 2017 at 4:00 p.m. in SOM E-501.

The title of Stephan's dissertation is, "Insights into the Functional Roles of Exercise in Type 2 Diabetes Using In Vitro Models."

A reception was held after the defense at 5:00 p.m. in the Department's 5th floor bridge area in honor of the newly minted Ph.D.

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Welcome to Dr. Nikhil Bharambe
Sept. 1, 2017

Nikhil Bharambe, Ph.D. has joined the lab of Dr. Rajesh Ramachandran as a Postdoctoral Scholar, effective September 1, 2017.

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Welcome to Jake Popple
Aug. 28, 2017

Jacob Popple. B.S., a student in the Department's Master of Science in Medical Physiology program, has joined the lab of Dr. Walter Boron as a Research Assistant, effective August 28, 2017.

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Annual DPB Baseball Outing
Aug. 25, 2017 7:10 p.m.

The Department hosted its annual baseball outing on Friday, August 25, when the Cleveland Indians played the Kansas City Royals at Progressive Field downtown at 7:10 p.m. The Indians won 4-0!

We host the baseball outing at the beginning of each new academic year to welcome our new students and to provide an enjoyable event for returning students, faculty, and staff. Tickets are complimentary for our students and department associates, and all include club privileges.

Image: Annie O'Neill

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Welcome to our M.S.M.P. 2017 Entering Class
Aug. 25, 2017

The Department welcomed its Master of Science in Medical Physiology program 2017 entering class this week with the first day of orientation on Thursday, August 24. New students attended general orientation sessions, as well as sessions on time management, study skills, and test-taking skills, and participated in a group photo (left).

The first day of orientation concluded with a catered reception in the School of Medicine main lobby area.

New M.S.M.P. students and other students and associates of the Department who reserved tickets attended a Cleveland Indians baseball game outing sponsored by the Department on Friday evening, August 25.

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Annual Department Summer Picnic
Aug. 10, 2017 3 p.m. - 7 p.m.

The Department hosted its annual summer picnic for our associates, their family members, and significant others on Thursday, August 10, 2017 from 3:00 - 7:00 p.m. at the Cleveland Botanical Garden in University Circle.

Catering was by Bon Appétit.

 

 

Image: Walter F. Boron, M.D., Ph.D.

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Congratulations to Dr. Pam Sangwung
July 6, 2017 3 p.m.

Panjamaporn (Pam) Sangwung publicly defended her doctoral dissertation on Thursday, July 6, 2017 at 3:00 p.m. in SOM E-501.

The title of Pam's dissertation is "Kruppel-Like Transcription Factors: Master Regulators of Vascular Endothelium."

Pam's mentor is Mukesh K. Jain, M.D. (photo left)

A reception in Pam's honor was held following the defense in the Department's 5th floor bridge area.

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Special DPB Seminar
July 5, 2017 4 p.m. - 5 p.m.

The Department hosted a special seminar presented by Michael Decker, Ph.D., R.N., R.R.M., Diplomate A.B.S.M, an Associate Professor at the Case Western Reserve University Frances Payne Bolton School of Nursing, on Wednesday, July 5, 2017 at 4:00 p.m. in SOM E-501.

The title of Dr. Decker's seminar was "Mechanisms through which hypoxia-induced dopamine dysfunction could enhance vulnerability for substance misuse."

Dr. Decker is also a Principal Investigator and the Laboratory Director in the Bolton School of Nursing Neuroscience Lab.

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Welcome to Bridget Kennedy
July 3, 2017

Bridget Kennedy, B.A., B.S., M.S. has joined the lab of Dr. Rajesh Ramachandran as a Research Assistant II, effective July 3, 2017.

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Congratulations to Dr. Xin Qi
July 1, 2017

Xin Qi, Ph.D. has been promoted to Associate Professor, with tenure, in the Department of Physiology and Biophysics, effective July 1, 2017.

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Congratulations to Dr. Chris Ford
July 1, 2017

Christopher P. Ford, Ph.D. has been promoted to Associate Professor, with tenure, in the Department of Physiology and Biophysics, effective July 1, 2017.

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Congratulations to Dr. Sudha Chakrapani
July 1, 2017

Sudha Chakrapani, Ph.D. has been promoted to Associate Professor, with tenure, in the Department of Physiology and Biophysics, effective July 1, 2017.

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Congratulations to Dr. Rajesh Ramachandran
June 27, 2017

Rajesh Ramachandran, Ph.D., an Assistant Professor in the Department of Physiology and Biophysics, has been awarded, for a term of 5 years, an R01 grant by the National Institutes of Health for research on "Molecular mechanisms of dynamin-related protein 1-mediated mitochondrial fission."

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Welcome to Dr. Jamie Prezioso
June 26, 2017

Jamie Prezioso, Ph.D. joined the lab of Dr. Walter Boron as a Postdoctoral Scholar/Mathematician on June 26, 2017.

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Post-Bacc Application Deadline
June 19, 2017

June 19th, 2017 at midnight was the official deadline for submitting applications for the MS in Medical Physiology Program (Post-Bacc Program).  The admissions committee will review your application once it is complete and all application materials are received.  If you have any questions, please contact Dr. Nosek (thomas.nosek@case.edu, 216-368-3242). Contact us if you need assistance.

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Congratulations to C. W. Gallagher...
June 19, 2017

on his award of a Summer Student Fellowship grant by the organization Fight for Sight.

C.W. is a student in the Master's in Medical Physiology program.

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Open House for Post-Bacc Medical Physiology Program
June 3, 2017 10 a.m. - 4 p.m.

The Department will host an Open House on Saturday, April 7 and Saturday, June 2, 2018.  Prospective received information about our educational programs, toured the CWRU campus and department laboratories, and met faculty and students.

For more information: https://physiology.case.edu/education/department-open-house/

 

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Congratulations to Dr. Pamela Marcott
June 2, 2017 3 p.m.

Pamela Marcott, an M.D./Ph.D. candidate in the Medical Science Training Program (MSTP), mentored by and in the lab of Dr. Chris Ford, publicly defended her doctoral dissertation at 3:00 p.m. on Friday, June 2, 2017 in SOM E-501.

The title of Dr. Marcott's dissertation is "Mechanisms of dopamine D2-receptor activation across the striatum."

A reception in Pam's honor was held followng the defense.

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Congratulations to Dr. Sandip Basak...
June 2, 2017

on his American Heart Association AWRP Winter 2017 Postdoctoral Fellowship two-year award* for the project “Effects of cholesterol and polyunsaturated fatty acids on ligand-gated ion channel structure and function,” effective July 1, 2017. Dr. Basak is a Postdoctoral Fellow in the lab of Dr. Sudha Chakrapani.

*Percentile Rank: 0.15%

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Congratulations to our M.S.M.P. graduates
May 21, 2017

Eighty-nine students in the Department's Master of Science in Medical Physiology program were awarded M.S. degrees on Sunday, May 21.

These were in addition to eighteen students in the program who graduated in December 2016.

Eight of the degrees awarded on Sunday were for the joint M.S./M.B.A. program.

Best wishes to our graduates as they begin the next stage of their lives!

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Congratulations to Dr. Jeff Garvin
May 3, 2017

Dr. Garvin received the 2017 J. Bruce Jackson M.D. Award for Excellence in Undergraduate Mentoring. The award, which is in the form of an apple, was presented to Dr. Garvin by University President Barbara Snyder on May 3, 2017.

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4th Annual M.S.M.P. Cardigan Day
April 20, 2017

In 2013, the Master of Science in Medical Physiology first year students conspired to all come to morning lecture wearing cardigan sweaters. The lecturer for that day, Dr. Tom Nosek, a regular wearer of cardigan sweaters "since birth", didn't notice that everyone was wearing one until it was pointed out to him.

Every Spring since, Dr. Nosek proclaims a "Cardigan Day" for the first year M.S.M.P. students and asks them to wear a cardigan to lecture. Today was that day for the class entering in Fall 2016.

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Congratulations to Dr. Drew Nassal
March 31, 2017

Drew Nassal, a Ph.D. candidate advised by and in the lab of Dr. Isabelle Deschenes, publicly defended his doctoral dissertation on Friday, March 31 at 3:00 p.m. in SOM E-501.

Dr. Nassal's dissertation is entitled "Evaluating Non-canonical Roles of KChIP2 in the Heart."

A reception for Dr. Nassal and his family followed the defense in the Department of Physiology and Biophysics 5th floor bridge area.

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5th Annual Ulrich Hopfer Lecture
March 22, 2017 4 p.m. - 5 p.m.

Dr. Amira Klip, a Senior Scientist in the Cell Biology Program at the Hospital for Sick Childen in Toronto and a professor in the Departments of Pediatrics, Biochemistry, and Physiology at the University of Toronto, gave the 5th annual Ulrich Hopfer lecture, hosted by Dr. Walter Boron and Dr. Ulrich Hopfer and the Department of Physiology and Biophysics, on Wednesday, March 22, 2017 at 4:00 p.m in SOM E-501.

The title of Dr. Klip's lecture was "Insulin and exercise signals mobilizing glucose transporters in muscle cells."

The Department hosts the Hopfer lecture each Spring to honor Professor Emeritus Ulrich Hopfer, M.D., Ph.D.

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Congratulations to the Stelzer Lab...
March 10, 2017

...on the publication of their cardiac muscle research, entitled “Cardiac myosin binding protein-C Ser302 phosphorylation regulates cardiac β-adrenergic reserve.”

Science Advances,10 Mar 2017: Vol. 3, no. 3, e1602445, DOI: 10.1126/sciadv.1602445

Ranganath Mamidi*, Kenneth S. Gresham*, Jiayang Li, and Julian E. Stelzer

 

 

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Congratulations to Dr. Matthias Buck & Dr. Andrew Li...

Congratulations to Dr. Jeff Garvin and Casandra Monzon...
March 8, 2017

on the publication of the manuscript "Nitric Oxide Reduces Paracellular Resistance in Rat Thick Ascending Limbs by Increasing Na+ and Cl- Permeabilities."

Monzon CM, Occhipinti R, Pignataro OP, Garvin JL

Am J Physiol Renal Physiol. 2017 Mar 8:ajprenal.00671.2016. doi: 10.1152/ajprenal.00671.2016. [Epub ahead of print]

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Congratulations to the Chakrapani Lab...
March 6, 2017

...on the acceptance of the manuscript, "Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel" by eLife.

Sandip Basak*, Nicolaus Schmandt*, Yvonne Gicheru*, and Sudha Chakrapani

*equal contribution

 

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Congratulations to Rajesh Ramachandran, Ph.D.
March 1, 2017

Dr. Ramachandran received an R21 award from the National Institute for Neurological Diseases and Stroke for research on Molecular Mechanisms of Rapid Synaptic Vesicle Endocytosis..

The award period is March 1, 2017 - February 28, 2019

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Congratulations to Joseph C. LaManna, Ph.D.
Feb. 27, 2017

Dr. LaManna has been elected a Fellow of the American Association of Anatomists.

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Congratulations to Dr. Matthias Buck...
Feb. 8, 2017

on the publication of "Molecular Dynamics Simulations Reveal Isoform Specific Contact Dynamics between the Plexin Rho GTPase Binding Domain (RBD) and Small Rho GTPases Rac1 and Rnd1."

Zhang L, Buck M

J Phys Chem B. 2017 Feb 23;121(7):1485-1498. doi: 10.1021/acs.jpcb.6b11022. Epub 2017 Feb 8.

Liqun Zhang, Ph.D. was formerly a postdoctoral scholar in Dr. Buck's lab.

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Congratulations to the LaManna Lab...
Feb. 8, 2017

on the publication of the manuscript, "Gender differences in hypoxic acclimatization in cyclooxygenase-2 deficient mice."

Xu K, Sun X, Benderro GF, Tsipis CP, LaManna JC. Physiol Rep. 2017 Feb;5(4). pii: e13148. doi: 10.14814/phy2.13148. Epub 2017 Feb 27.

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DPB Holiday Party
Dec. 3, 2016 6:30 p.m. - 10:30 p.m.

The Department hosted its annual holiday party on Saturday, December 3, 2016 from 6:30 - 10:30 p.m. at the Western Reserve Historical Society in University Circle.

Associates of the Department and their families and significant others as well as additional guests of the Department attended.

Catering was by A Taste of Excellence and a string quintet performed for the event.

 

 

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Congratulations to Dr. Xin Qi...
Dec. 1, 2016

on acceptance of the manuscript “VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington’s disease.”

BBA - Molecular Basis of Disease

Xing Guo, Ph.D. and Xin Qi, Ph.D., In press

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Congratulations to Dr. Jin-Kyu Choi and the Surewicz Lab...
Nov. 14, 2016

on the publishing of the paper “Amyloid fibrils from the N-terminal prion protein fragment are infectious” in the Proceedings of the National Academy of Sciences USA.

Jin-Kyu Choi, Ignazio Cali, Krystyna Surewicz, Qingzhong Kong, Pierluigi Gambetti, and Witold K. Surewicz

Proc Natl Acad Sci USA 2016; published ahead of print November 14, 2016, doi:10.1073/pnas.1610716113.

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Congratulations to Didi Mamaligas and Yuan Cai...
Nov. 10, 2016

on the acceptance of the paper “Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission.”

Scientific Reports (In press)

Didi and Yuan are Ph.D. candidates in the lab of Dr. Chris Ford.

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Welcome Deng-ke Wang, Ph.D.
Oct. 24, 2016

Deng-ke Wang, Ph.D. has joined the lab of Dr. Walter Boron as a postdoctoral scholar, effective October 24, 2016

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DPB Frontiers in Biological Sciences Lecture
Oct. 19, 2016 4 p.m.

Dr. Christopher Ford and Dr. Sudha Chakrapani hosted Dr. Eric Gouaux at the 2016 Department of Physiology and Biophysics-sponsored Frontiers in Biological Sciences Lecture on Wednesday, October 19 at 4:00 p.m. in SOM E-501.

Dr. Gouaux's lecture was entitled "Music of the brain illuminated by molecular studies of the instruments:  X-rays and electrons reveal architecture and mechanism of neurotransmitter receptors and transporters."

Eric Gouaux, Ph.D. is an Investigator at the Howard Hughes Medical Institute and a Senior Scientist at the Vollum Institute and holds the Jennifer and Bernard Lacroute Term Chair in Neuroscience Research at the Oregon Health & Science University.

A pre-lecture reception was held at 3:30 p.m. in the Department lobby.

 

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2nd Annual Matthew Levy Lecture
Oct. 7, 2016 4 p.m.

The Department hosted the 2nd Annual Matthew Levy Lecture on Friday, October 7, 2016 at 4:00 p.m. in Room E-501 of the School of Medicine.

The guest lecturer was Jonathan A. Epstein, M.D., the Executive Vice Dean and Chief Scientific Officer, and the William Wikoff Smith Professor of Cardiovascular Research at the Perelman School of Medicine of the University of Pennsylvania.

Dr. Epstein's lecture was titled "Regulation of nuclear architecture drives cell fate."

A reception was held prior to the lecture at 3:15 p.m. in the Department lobby.

The late Dr. Matthew Levy was a gifted, dedicated teacher and scientist who influenced countless students, conducted groundbreaking research on heart function and its relationship to the autonomic nervous system, and who co-authored one of the most influential texts on physiology. Each autumn, beginning with a daylong symposium in 2014, the Department honors the memory of Dr. Levy and his accomplishments.

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2016 Department Retreat / Recknagel Symposium
Sept. 23, 2016 7:30 a.m. - 4:45 p.m.

The 2016 Recknagel Symposium took place at the Department's annual retreat at the Cleveland Convention Center on Friday, September 23, 2016.

Three of the Department's second year doctoral students, Michael Babinchak, Yuan Cai, and Nitish Rana, presented on projects from their first year laboratory rotations. Yuan Cai won the Recknagel awards for both his presentation and for academic record.

The Department established the annual Recknagel Symposium in memory of Professor Richard Recknagel, who was Chairman of the Department of Physiology from 1976 to 1986 and an admired thinker and investigator who took a keen interest in mentoring young students and faculty.

 

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2016 Recknagel Symposium
Sept. 23, 2016

The 2016 Recknagel Symposium took place at the Department's annual retreat on Friday, September 23, 2016 at the Huntington Convention Center in downtown Cleveland.

Three of the Department's second year doctoral students, Michael Babinchak, Yuan Cai, and Nitish Rana, presented on projects from their first year laboratory rotations. Yuan Cai won the Recknagel awards for both his research presentation and for academic achievement. The title of Yuan's presentation was "Acetylcholine regulation of dopamine D2 receptor mediated transmission in striatal medium spiny neurons."

The Department established the annual Recknagel Symposium in memory of Professor Richard Recknagel, who was Chairman of the Department of Physiology from 1976 to 1986 and an admired thinker and investigator who took a keen interest in mentoring young students and faculty.

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Congratulations to Dr. Xin Qi...
Sept. 13, 2016

on the acceptance of the paper “Inhibition of Drp1 mitochondrial translocation provides neuronal protection in dopaminergic system in a Parkinson’s disease model induced by MPTP”

Scientific Reports, 2016 Sep 13;6:32656.

Filichia E, Hoffer B, Qi X*, Luo Y*

*co-corresponding author

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Congratulations to Dr. Ahlam Salameh
Sept. 6, 2016 3:30 p.m.

Ahlam Salameh publicly defended her doctoral dissertation on Tuesday, September 6, 2016 at 3:30 p.m. in SOM E-501.

The title of Dr. Salameh's dissertation is "Metabolic acidosis and the mysterious role of the anion exchanger AE3 in the intracellular-pH physiology of hippocampal neurons and astrocytes".

Ahlam was advised by and in the lab of Dr. Walter Boron, the Myers/Scarpa Professor and Chair of the Department of Physiology and Biophysics.

A reception in Ahlam's honor, with her family in attendance, followed the defense at 5:00 p.m.

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Annual Department Baseball Outing - Indians vs. Marlins
Sept. 2, 2016 7:10 p.m.

The Department will host its annual baseball outing on Friday, September 2 at Progressive Field in downtown Cleveland. The Cleveland Indians will play the Miami Marlins at 7:10 p.m.

Faculty, students, postdocs, and staff members may reserve a complimentary ticket with club privileges, which includes all food concessions at no cost. Additional tickets with club privileges are available for purchase at a price of $62.00 each.

The Department hosts the baseball outing at the beginning of each academic year to welcome our new Ph.D. and M.S. students.

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Welcome Mentor Mulaj, Ph.D.
Sept. 1, 2016

Mentor Mulaj, Ph.D. has joined the lab of Dr. Witold Surewicz as a postdoctoral scholar, effective September 1, 2016.

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Welcome 2016 Masters in Medical Physiology Students
Aug. 25, 2016

The department welcomed the Master’s in Medical Physiology class matriculating in 2016. These students come from 26 different states, 8 foreign countries, and 111 different colleges and universities. This is the sixth class in the MSMP program.

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Congratulations to the Lab of Dr. Xin Qi...
July 22, 2016

on the acceptance of the paper “VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease” by Nature / Communications

Xing Guo, Xiaoyan Sun,  Di Hu, Yajuan Wang, Dr. Hisashi Fujioka, Rajan Vyas, Sudha Chakrapani, Amit Joshi, Yu Luo and Xin Qi.

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Department Annual Summer Picnic
July 15, 2016 noon - 4 p.m.

The Department hosted its annual summer picnic on Friday, July 15, 2016 from noon to 4:00 p.m. at the University's Squire Valleevue farm in Hunting Valley.

A barbecue menu was catered by A Taste of Excellence.

 

Image: en.wikipedia.org

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Congratulations to Hana Russo...
July 6, 2016

...on the acceptance of the paper as first author, based on her dissertation research,

“Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides”

Hana M. Russo,  Joseph Rathkey,  Andrea Boyd-Tressler,  Michael A. Katsnelson,  Derek W. Abbott,  and George R. Dubyak.

J Immunol 1600699; published ahead of print July 6, 2016, doi:10.4049/jimmunol.1600699

Hana, a student in the Medical Scientist Training Program, is a Ph.D. candidate in Pathology in the lab of Dr. George Dubyak.

Andrea Boyd-Tressler, a Ph.D. graduate of the Dubyak lab in Pharmacology, has begun her 1st year as an M.D. candidate at the Lerner Cleveland Clinic College of Medicine of CWRU.

Michael Katsnelson, a student of the Medical Scientist Training Program and a Ph.D graduate of the Dubyak lab in Pathology, is currently completing his final year as an M.D. candidate at the Case School of Medicine.

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Congratulations to Ahlam Salameh
July 5, 2016

Ahlam, a Ph.D. candidate in the lab of Dr. Walter Boron, has had a Perspectives editorial article to accompany her recently accepted second paper,

"Role of Cl-HCO3 exchanger AE3 in intracelllular-pH homeostatis in cultured murine hippocampal neurons, and in crosstalk to adjacent astrocytes"

commissioned by the The Journal of Physiology.

Ahlam I. Salameh, Christian A. Hübner, and Walter F. Boron. J. Physiol, June 2016

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Congratulations to Dr. Julian Stelzer
July 1, 2016

Julian Stelzer, Ph.D. has been promoted to Associate Professor, effective July 1, 2016.

Dr. Stelzer joined the Department of Physiology and Biophysics as a Visiting Professor and was named an Assistant Professor in February 2009.

 

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Post-Bacc Application Deadline
June 15, 2016

June 15th, 2016 at midnight is the official deadline for submitting applications for the MS in Medical Physiology Program (Post-Bacc Program). Any online applications that have been initiated at that time will be considered even if it takes the applicant a week or so to complete the application (ex. provide your official transcript, provide GRE, MCAT, or DAT scores, provide your personal statement, provide 3 letters of recommendation).  The admissions committee will review your application once it is complete and all application materials are received.  If you have any questions, please contact Dr. Nosek (Thomas.Nosek@Case.edu, 216-368-3242). Contact us if you need assistance.

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2016 Summer Research Interns
June 13, 2016

The Department is hosting six summer research interns from Alfaisal University in Saudi Arabia. We welcome

  • Khaled Helmi (Ramachandan lab)
  • Mohamad Saleh Alabdaljabar (Mu lab)
  • Dalia Sriwi (Romani lab)
  • Sara Kayali (Smith lab)
  • Hajar Alreefi (Qi lab)
  • Mayar Helaly (Romani lab)
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Open House for Post-Bacc Medical Physiology Program
June 4, 2016 10 a.m.

The Department held an Open House on Saturday, June 4th, 2016.  Prospective students received information about our educational programs, toured the CWRU campus and department laboratories, and met faculty and students. Please click here for more info.

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Congratulations to Dr. Ken Gresham
May 27, 2016

Ken Gresham (photo right), a Ph.D. candidate in the lab of Dr. Julian Stelzer (photo left), publicly defended his doctoral dissertation on Friday, May 27, 2016 at 2:30 p.m. in SOM E-501.

The title of Ken's dissertation is "MyBP-C Phosphorylation Regulates Ventricular Pressure Development and Relaxation."

A reception in Ken's honor catered by A Taste for Excellence followed the defense at 3:30 p.m. in the 5th floor bridge area.

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Congratulations to Dr. Ranganath Mamidi
May 25, 2016

Dr. Mamidi has been awarded a two-year Postdoctoral Fellowship by the American Heart Association, effective July 1, 2016, to study "Sarcomere-based pharmacological approach to rescue contractile dysfunction in dilated and hypertrophic cardiomyopathies."

Ranga is a member of the lab of Dr. Julian Stelzer.

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Congratulations to Dr. Chris Ford
May 24, 2016

Dr. Ford has been elected to serve on the NIH Molecular Neuropharmacology and Signaling (MNPS) study section for the term 2016-2020.

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Congratulations to Dr. Michael Katsnelson, Kristen Lozada-Soto & Hana Russo...
May 11, 2016

...on acceptance of the paper 

"NLRP3 Inflammasome Signaling is Activated by Low-Level Lysosome Disruption but Inhibited by Extensive Lysosome Disruption: Roles  for K+ Efflux and Ca2+ Influx."

Katsnelson MA, Lozada-Soto KM, Russo HM, Miller BA, Dubyak GR. Am J Physiol Cell Physiol. 2016 May 11:ajpcell.00298.2015. doi:10.1152/ajpcell.00298.2015. [Epub ahead of print] PubMed PMID: 27170638.

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Congratulations to Pam Marcott
April 27, 2016

Pam Marcott, a Ph.D. candidate in the lab of Dr. Chris Ford, was awarded a National Research Service Award Predoctoral Research Fellowship (F30) by the National Institute on Drug Abuse (NIDA) of NIH for research on "Functional properties of dopamine and glutamate cotransmission in the nucleus accumbens," effective March 8, 2016.

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Congratulations to Dr. Walter Boron
April 26, 2016

Walter Boron, M.D., Ph.D., the Myers/Scarpa Professor and Chair of the Department of Physiology and Biophysics, has been awarded a five-year Multidisciplinary University Research Inititative (MURI) grant from the Office of Naval Research, effective June 1, 2016, for the research topic, "Molecular mechanisms and pathways for gas transport across biological membranes and implications for physiology and performance."

The University of Southern California and the University of Illinois at Urbana-Champaign are also participating in this research.

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Congratulations to Dr. Sudha Chakrapani
April 21, 2016

Dr. Chakrapani has been elected to the Council of the Society of General Physiologists for the term 2015 - 2018.

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Congratulations to Dr. Nick Courtney
April 21, 2016

Dr. Courtney, who was awarded a Ph.D. on October 30, 2015, has received a Graduate Excellence Award from the CWRU School of Graduate Studies. Nick was a member of the lab of Dr. Chris Ford and is currently a postdoctoral fellow in the lab of Dr. Edwin Chapman at the Howard Hughes Medical Institute at the University of Wisconsin - Madison.

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Congratulations to Dr. Julian Stelzer
April 18, 2016

Dr. Stelzer has been awarded a BRS Shared Instrumentation Grant (S10) by the National Institutes of Health for research on "High resolution ultrasound for small animal imaging," effective May 1, 2016.

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Open House for Post-Bacc Medical Physiology Program
April 9, 2016 10:30 a.m.

The Department has scheduled an Open House for April 9th, 2016.  Prospective students can hear all about our educational programs, tour the CWRU campus and department laboratories, and meet faculty and students. Please click here for more info.

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Grad Student Appreciation event
April 7, 2016 8 a.m. - 11 a.m.

A buffet continental breakfast was served in the Department of Physiology and Biophysics lobby in honor of the students in our graduate programs on Thursday morning, April 7.

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Special Lecture and Department Visit
April 6, 2016 - April 9, 2016

Our Department chair, Dr. Walter Boron, hosted Prof. Dr.med. Ulrich Pohl for a four-day visit that included a special lecture at 1:00 p.m. on Friday, April 8.

Prof. Dr. Pohl is a Professor and Chair of Vegetative Physiology at the Institute of Cardiovascular Physiology and Pathophysiology, and Director of the Walter Brendel Centre for Experimental Medicine at Ludwig Maximilians University in Munich.

Prof. Dr. Pohl's lecture was entitled "Vascular connexins, all-rounders which mind more than just a gap (junction)". A reception was held at the conclusion of the lecture.

Dr. Pohl's visit also included a facutly dinner, meetings with individual faculty members, as well as a visit to the Cleveland Museum of Art and attendance of a concert of the Cleveland Orchestra.

 

 

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4th Annual Ulrich Hopfer Lecture
March 17, 2016

Dr. Ernest Wright, FRS, of the UCLA School of Medicine, presented the 4th annual Ulrich Hopfer lecture, hosted by Dr. Walter Boronand the Department of Physiology and Biophysics, on Thursday, March 17, 2016 at 4:00 p.m in SOM E-501.

Dr. Wright's lecture was titled “Basic Physiology to Translational Medicine: Lessons from SGLTS.“

Dr. Wright and Dr. Hopfer were honored at a reception and dinner on Wednesday evening at the Cleveland Museum of Art.

The Department hosts the Hopfer lecture each Spring to honor Professor Emeritus Ulrich Hopfer, M.D., Ph.D.

 

 

 

 

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Congratulations to Dr. Chris Ford & Dr. Nick Courtney...
Jan. 7, 2016

on acceptance of the paper "Mechanisms of 5HT1A receptor mediated transmission in dorsal raphe serotonin neurons."

Courtney NA & Ford CP (2016), Journal of Physiology. In press.

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Congratulations to Dr. Mausita Karmakar & Dr. Michael Katsnelson...
Dec. 28, 2015

on acceptance of the paper "Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP."

Karmakar M., Katsnelson, M., Dubyak G.R., Pearlman, E., Nature / Communications. In press.

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DBP 2015 Holiday Party
Dec. 18, 2015 3 p.m. - 6:30 p.m.

The Department hosted its annual holiday party on Friday, December 18 from 3:00 - 6:30 p.m. in the 5th floor bridge area.

Catering was provided by A Taste of Excellence. The menu included short ribs, chicken tenders, premium beef sliders, artichoke dip, and finger pastries, as well as wine, beer, and soft drinks.

 

We had quite a number of guests from outside of the Department, and the attendees seemed to have an enjoyable time.

 

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Congratulations to Dr. Michelle Jennings Nassal
Nov. 20, 2015

Michelle Jennings Nassal publicy defended her doctoral dissertation on Friday, November 20 at 2:00 p.m. in SOM Robbins E-501.

The title of Dr. Jennings Nassal's dissertation is "Identifying Novel Therapeutic Targets for Reentrant Amhythimias."

A reception followed the defense at 3:00 p.m. in the Department of Physiology and Biophysics fifth floor bridge area.

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Congratulations to Dr. Matt Cohen
Nov. 6, 2015

Matt Cohen, a doctoral candidate in the lab of Dr. Vera Moiseenkova-Bell, publicy defended his dissertation on Friday, November 6 at 3:30 p.m. in SOM Robbins E-501.

The title of Dr. Cohen's dissertation is "Regulation of endogenous TRV2 ion channel by growth factors in neuronal cells".

A reception followed the defense at 4:30 p.m. in the Department of Physiology and Biophysics fifth floor bridge area.

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Congratulations to Dr. Nick Courtney
Oct. 30, 2015

Nick Courtney, a Ph.D. candidate in the lab of Dr. Chris Ford, publicly defended his doctoral dissertation on Friday, October 30, 2015 at 3:00 p.m. in SOM Robbins E-504.

The title of Nick's dissertation is “Mechanisms of autoreceptor-mediated inhibition in central monoamine neurons.”

A reception followed the defense at 4:00 p.m. in the Department of Physiology and Biophysics fifth floor bridge area.

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1st Annual Matthew Levy Lecture
Oct. 12, 2015 3 p.m. - 4 p.m.

The Department hosted the First Annual Matthew Levy Lecture at 3:00 p.m. on Monday, October 12, 2015 in SOM Robbins E-501.

The guest lecturer was Dr. Peter Libby, the Mallinckrodt Professor of Medicine and a cardiovascular specialist at Harvard Medical School and Brigham and Women's Hospital.

 

The title of Dr. Libby's lecture was “Inflammation in Atherosclerosis –a Translational Journey”.

A pre-lecture reception was held at 2:30 p.m. in the Department's lobby.

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Welcome Andrew Zhen-Li, Ph.D.
Oct. 5, 2015

Andrew has joined the lab of Dr. Matthias Buck as a postdoctoral scholar, effective October 5, 2015.

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Congratulations to Dr. Walter Boron
Sept. 28, 2015

Dr. Walter Boron, the Myers/Scarpa Professor and Chair of the Department of Physiology and Biophysics, received a DURIP award from the Office of Naval Research for equipment for gas channel research, effective August 15, 2015.

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2015 Recknagel Symposium
Sept. 25, 2015 2:30 p.m. - 4 p.m.

The annual Recknagel Symposium was held, as a part of the Department Annual Retreat at the Kalihari Resort, on Friday afternoon, September 25, from 2:30 - 4:00 p.m. Six of our second year doctoral students presented on projects from their first year laboratory rotations.

 

Winners of the 2015 Recknagel Symposium awards are:

Yvonne Gicheru, Ph.D. candidate - Best research presentation for "Pentameric Ligand-Gated Ion Channels Analyzed By Nanodisc Technology". Yvonne is in the lab of Dr. Sudha Chakrapani.

Di Hu, Ph.D. candidate - Best academic record (2014-2015). Di is in the lab of Dr. Xin Qi.

During the first year of doctoral training, students in the Department rotate in three different laboratories. The goal of these rotations is to identify a subject area of interest, and a mentor for future research. After completion of the research rotations, each student presents one of the projects to the entire department at the Recknagel Symposium.

Professor Richard Recknagel was Chairman of Physiology from 1976 to 1986. He was an admired thinker and investigator who took a keen interest in mentoring young students and faculty. In his memory, the Department established this Symposium.

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2015 DPB Annual Retreat and Recknagel Symposium
Sept. 24, 2015 - Sept. 25, 2015

The Department of Physiology and Biophysics held its annual retreat at the Kalahari Resort in Sandusky, OH on Thursday and Friday, September 24 and 25, 2015.

The annual Recknagel Symposium also took place, as part of the retreat, on Friday afternoon, September 25. Six of our second year doctoral students presented on projects from their first year laboratory rotations.

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Congratulations to Dr. Rossana Occhipinti
Sept. 18, 2015

Congratulations to Rossana Occhipinti, Ph.D. on the award of a K01 grant from the National Institute of Diabetes and Digestive and Kidney Diseases for the project:

"Acid secretion and intracellular pH regulation in proximal-tubule cells"

The award was effective on September 18, 2015 and the project will run through August 31, 2020.

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Welcome postdoc Mukesh Mahajan
Sept. 10, 2015

Mukesh Mahajan, PhD. joined the lab of Dr. Matthias Buck as a postdoctoral scholar, effective September 10, 2015.

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Annual DPB Baseball Outing
Aug. 28, 2015 7:10 p.m.

The Department hosted its annual baseball outing on Friday evening, August 28, 2015.

The Cleveland Indians beat the Los Angeles Angels, 3-1, at Progressive Field.

The annual event provides a special welcome to our new students, as well as providing an enjoyable evening for other attendees from the Department. A happy hour on campus preceded the game.

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Welcome 2015 Masters in Medical Physiology Students
Aug. 24, 2015

The Department welcomed the Masters in Medical Physiology Class matriculating in 2015. These students come from 27 different states, 5 foreign countries, and 80 different colleges and universities. This is the fifth class in the MSMP program.

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Congratulations to Dr. Michael Katsnelson
July 30, 2015

Michael Katsnelson, a Ph.D. candidate in the lab of Dr. George Dubyak and a student in the Medical Scientist Training Program, successfully defended his doctoral dissertation on Thursday, July 30, 2015.

The title of Dr. Katsnelson's dissertation is "Cation Channels as regulators and effectors of NLRP3 inflammasome signaling and IL-1 beta secretion".

The new Ph.D. will begin his third year in the M.D. program at the School of Medicine in the Fall semester.

A reception in Dr. Katnelson's honor was held in the afternoon after the completion of the defense.

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Congratulations to Dr. Daniel Harris
July 27, 2015

Daniel Harris, a Ph.D. candidate in the lab of Dr. Paul DiCorleto, successfully defended his doctoral dissertation on Monday, July 27, 2015.

The title of Dr. Harris's dissertation is “PRMT5-Catalyzed Arginine Methylation of NF-KB p65 in the Endothelial Cell Induction of Pro-Inflammatory Chemokines”.

A reception was held in honor of the new Ph.D. after the completion of the defense.

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Physiology & Biophysics Annual Summer Picnic
July 17, 2015 3 p.m. - 7 p.m.

The Department hosted its annual picnic on Friday, July 17 from 3:00 - 7:00 p.m. at CWRU's Squire Valleevue Farm in Hunting Valley.

A barbecue menu was catered by A Taste of Excellence.

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Congratulations to Dr. Christina Antonopoulos Buzzy and Hana Russo...
June 26, 2015

as first and second author, respectively, on acceptance of the paper, “Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling”

Christina received her Ph.D. in Pathology in December 2014, having done her doctoral research in the lab of Dr. George Dubyak.  She is currently a postdoctoral scholar in the Department of Medicine in the lab of Dr. Anne Hamik, a member of the Department of Physiology and Biophysics secondary faculty.

Hana is an M.D./Ph.D. graduate student in the Pathology Ph.D. program (Immunology Track), also in the lab of Dr. George Dubyak.

 J Biol Chem. 2015 Jun 22. pii: jbc.M115.652321. [Epub ahead of print]

Antonopoulos C, Russo HM, El Sanadi C, Martin BN, Li X, Kaiser WJ, Mocarski ES, Dubyak GR

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Congratulations to Dr. Ranga Mamidi
June 22, 2015

Congratulations to Dr. Ranga Mamidi on acceptance of the paper

“Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C”

Journal of Molecular and Cellular Cardiology, 2015 (in press)

 

Ranganath Mamidi, Ph.D., Kenneth S. Gresham, Ami Li, Cristobal G. dos Remedios, Ph.D., Julian E. Stelzer, Ph.D.

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Open House for Post-Bacc Medical Physiology Program
May 30, 2015

The Department hosted an Open House for the MS in Medical Physiology Program on Saturday, May 30th.  Prospective students and family members heard all about our Masters in Medical Physiology program, toured the CWRU campus and department laboratories, and met faculty and students. Please click here for more information.

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Congratulations to Peyvand Amini
May 8, 2015

Peyvand won the first place poster presentation award at the 38th Biomedical Graduate Student Symposium on May 8th, 2015.

The poster was for the project "Post-Translational Modifications of Progesterone Receptor in Human Myometrium".

Peyvand is a Ph.D. candidate in the lab of Dr. Sam Mesiano in the Department of Reproductive Biology at University Hospitals-MacDonald Women's Hospital.

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Congratulations to Dr. Malcolm Hoshi
April 24, 2015

Malcolm Hoshi, a Ph.D. candidate with the lab of Dr. Isabelle Deschenes, successfully defended his Ph.D. dissertation in a public presentation on Friday, April 24, 2015.

The title of Dr. Hoshi's dissertation is “Unveiling Mechanisms Involved in Non-Traditional Cases of Inherited Cardiac Channelopathies”.

A reception was held following the public defense.

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Third Annual Ulrich Hopfer Lecture
April 22, 2015 4 p.m.

The Department of Physiology and Biophysics hosted the Third Annual Ulrich Hopfer Lecture on Wednesday, April 22, 2015.

The guest lecturer was Dr. Richard Johnson of the University of Colorado Anschutz Medical Campus in Aurora, CO.

Dr. Johnson's lecture was entitled “Fructose and its Role in Obesity and Metabolic Syndrome”.

 

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Congratulations to Dr. Ranganath Mamidi
April 17, 2015

Dr. Ranga Mamidi, a Postdoctoral Scholar in the lab of Dr. Julian Stelzer, won the Postdoctoral Research Award for his poster presentation at the 2015 Research ShowCASE.

Dr. Mamidi won the same award at the 2014 Research ShowCASE.

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Congratulations to Michael Katsnelson and Hana Russo
April 10, 2015

The manuscript “K+ Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+ Signaling”, submitted by Michael Katsnelson and Hana Russo, has been accepted for publication by the Journal of Immunology.

Michael and Hana are MD/PhD candidates in the Medical Sciences Training Program in Pathology (Immunology Track) and are in the lab of Dr. George Dubyak.

 

J Immunol., 2015 Apr 15; 194(8):3937-52. doi: 10.4049/jimmunol.1402658. Epub 2015 Mar 11.

Michael A. Katsnelson, L. Graham Rucker,  Hana M. Russo, and George R. Dubyak

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Welcome postdoc Saketh Chemuru
March 16, 2015

Saketh joined the lab of Dr. Witold Surewicz as a postdoctoral scholar, effective March 16, 2015.

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Congratulations Dr. Candida Desjardins
March 4, 2015

The Department of Physiology and Biophysics congratulates Dr. Candida Desjardins for successfully defending her PhD thesis, "Early Detection of Physiologic and Functional Changes of Common Structural Protein Mutations Underlying Human Diseases by MRI", on Mar 4th, 2015.

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Welcome postdoc Sandip Basak
Jan. 5, 2015

Sandip joined the lab of Dr. Sudha Chakrapani as a postdoctoral scholar, effective December 22, 2014.

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Welcome postdoc Rajan Vyas
Jan. 5, 2015

Rajan joined the lab of Dr. Sudha Chakrapani as a postdoctoral scholar, effective January 5, 2015.

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Welcome postdoc Mausita Karmakar
Jan. 5, 2015

Mausita joined the lab of Dr. George Dubyak as a postdoctoral scholar, effective January 1, 2015.

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2014 Holiday Party
Dec. 12, 2014 3 p.m. - 6:30 p.m.

The Department hosts a Holiday Party each December to celebrate all the diverse holidays observed by our department members.

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Matthew N. Levy Symposium
Oct. 1, 2014

The Department hosted the 2014 Matthew N. Levy Symposium on Oct. 1, 2014.  See this brochure for more information.

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2014 Department Retreat
Sept. 19, 2014 7:30 a.m. - Sept. 19, 2014 6:30 p.m.

The Department sponsored our annual Department Retreat on September 19th at the Cleveland Convention Center in Cleveland, Ohio. Retreats consisted of informal scientific presentations by principal investigators, students, and post-doctoral fellows.

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2014 Recknagel Symposium
Sept. 19, 2014

The Department held the 2014 annual Recknagel Symposium at its 13th Annual Retreat at the Cleveland Convention Center on Friday, September 19. Four second year doctoral students presented their research.

Peyvand Amini and Michael Glidden shared the award for best academic record and David Litvin took first place in the research presentation category. The title of David's presentation was “Central Indomethacin treatment following bleomycin induced lung injury attenuates breathing frequency & reduces brainstem IL-1B expression.”

During the first year of doctoral training, students in the Department rotate in three different laboratories. The goal of these rotations is to identify a subject area of interest, and a mentor for future research. After completion of the research rotations, each student presents one of the projects to the entire department at the Recknagel Symposium.

Professor Richard Recknagel was Chairman of Physiology from 1976 to 1986. He was an admired thinker and investigator who took a keen interest in mentoring young students and faculty. In his memory, the Department established this Symposium.

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Paper Acceptance: Andrea Boyd-Tressler
Aug. 11, 2014

Congratulations to Andrea Boyd-Tressler on the acceptance of her first paper as first author "Chemotherapeutic Drugs Induce ATP Release via Caspase-gated Pannexin-1 Channels and a Caspase/Pannexin-1-Independent Mechanism" in the Journal of Biological Chemistry.

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Open House for Post-Bacc Medical Physiology Program
May 31, 2014 10:30 a.m.

The Deparment has scheduled an Open House for May 31st.  Prospective students and family members can hear all about our Masters in Medical Physiology program, tour the CWRU campus and department laboratories, and meet faculty and students.  Deadline for registration is May 26th.  Please click here to register online for the event.  Please click here for more information.

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American Heart Association Summer Training Program
May 27, 2014 - Aug. 1, 2014

The Department of Physiology and Biophysics offers 5 summer research traineeships supported by a recently awarded American Heart Summer Training Grant.  The program is designed for outstanding students with majors in biology, chemistry, physics or related disciplines. Students will carry out a research project under the close guidance of a faculty member for 10 weeks during the summer months (May 27 through Aug. 1, 2014). In general, the program accepts students who have finished their junior year.
 

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2nd Annual Ulrich Hopfer Lecture
May 1, 2014 4 p.m.

The Department of Physiology & Biophysics established this Annual Lecture in honor of the accomplishments Ulrich Hopfer, M.D., Ph.D.  Dr. Hopfer is an internationally recognized scientist whose academic career spans over 35 years here at Case Western Reserve University.  During this time period, he distinguished himself for excellence in research and in teaching. Indeed, postdoctoral fellows, medical students, graduate students, and undergraduates have all benefited from his expertise.  Please join us as we welcome distinguished guest speaker, Christian Aalkjaer, MD., who will be presenting the 2014 Ulrich Hopfer Lecture on Thursday, May 1, 2014 at 4:00pm in the Robbins Building Auditorium, E-501

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Congratulations to Prattana Samasilp
March 18, 2014

The Department of Physiology and Biophysics congratulates Dr. Prattana Samasilp, for successfully defending her PhD thesis, "Molecular Control of Fusion Pore Expansion in Mouse Adrenal Chromaffin Cells", on Mar 18th, 2014.

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Paper Acceptance: Ross Anderson
March 11, 2014

Congratulations to Ross Anderson on the acceptance of his first paper as first author “Regulation of persistent activity in hippocampal mossy cells by inhibitory synaptic potentials” in Learning and Memory.

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Congratulations to Quentin Jamieson
Feb. 24, 2014

The Department of Physiology and Biophysics congratulates Dr. Quentin Jamieson, for successfully defending his PhD thesis, "The Inactivation Mechanisms of Shaker IR and KV2.1 Potassium Channels: Lessons from Pore Mutation", on Feb 24th, 2014.

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Congratulations to Sheela Toprani
Feb. 18, 2014

The Department of Physiology and Biophysics congratulates Dr. Sheela Toprani, for successfully defending her PhD thesis, "Mechanisms of Seizure Reduction by Low Frequency Electrical Stimulation", on Feb 18th, 2014.

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Post-Bacc MS in Medical Physiology Internet Program
Jan. 23, 2014

The Department of Physiology has just announced the option to take our popular Post-Bacc MS in Medical Physiology Program online.  See MSMP Internet Program for online program details.

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2013 Holiday Party
Dec. 13, 2013

The Department hosts a Holiday Party each December to celebrate all the diverse holidays observed by our department members.

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Paper Acceptance: Christina Antonopoulos
Nov. 1, 2013

Congratulations to Christina Antonopoulos on the acceptance of her first paper as first author “Pro-apoptotic Chemotherapeutic Drugs Induce Non-canonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells” in the Journal of Immunology.

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Open House for Physiology Graduate Programs
Oct. 12, 2013 10:30 a.m.

The Deparment has scheduled an Open Houses for October 12th.  Prospective students can hear all about our educational programs, tour the CWRU campus and department laboratories, and meet faculty and students. Please click here for more info.

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2013 Recknagel Symposium
Oct. 4, 2013 2:30 p.m. - 3:30 p.m.

This 2013 Recknagel Symposium was held during the Department's annual retreat on Friday, October 4 at the Sawmill Creek Resort in Huron, OH.

Four of our second year doctoral students presented on a project from their first year laboratory rotations. Pamela Marcott received the first place award for academic record and Pam (l) and Amrita Samanta (r) shared the first place award for research presentation.

Pam's presentation was entitled "“Light-evoked dopamine release induces a D2-receptor mediated inhibitory postsynaptic current” and Amrita' presentation was “Characterization of monoclonal antibodies to understand TRPV2 channel structure”

Professor Richard Recknagel was Chairman of Physiology from 1976 to 1986. He was an admired thinker and investigator who took a keen interest in mentoring young students and faculty. In his memory, the Department established this Symposium.

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2013 Department Retreat
Oct. 3, 2013 - Oct. 4, 2013

The Department will sponsor a Department Retreat on October 3rd and 4th at Sawmill Creek Resort in Huron/Sandusky, Ohio. Retreats consist of informal scientific presentations by principal investigators, students, and post-doctoral fellows.

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Paper Acceptance: Dr. Xin Qi
Sept. 12, 2013

Congratulations to Dr. Xin Qi on the acceptance of the paper “Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration” in the Journal of Clinical Investigation (in press).

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DPB Annual Baseball Outing
Aug. 23, 2013 7:05 p.m.

Students, staff, and faculty of the department will take the opportunity to enjoy an evening at Progressive Field.  The Indians will be playing the Minnesota Twins, it is Dollar Dog Night, and there will be fireworks.

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2013 Orientation
Aug. 21, 2013 - Aug. 23, 2013

The Department of Physiology and Biophysics will conduct an orientation for all new graduate program students.  Please follow this link for the orientation schedule

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Physiology Annual Picnic
July 12, 2013 3 p.m. - 7 p.m.

The department will be hosting our annual picnic at Squire Valleevue Farm.

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Dissertation Seminar: Seong-Ki Lee
June 20, 2013 noon

Molecular action of an electrogenic Na/HCO3 cotransporter (NBCe1)

 

Reception at 4:00 PM on 5th floor bridge

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Paper Acceptance: Dr. Xin Qi
June 20, 2013

Congratulations to Dr. Xin Qi on the publishing of the paper “Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation”* Human Molecular Genetics, June 27, 2013

*This paper is highlighted in Nature Review Neurology, titled as “Defective mitochondrial  dynamics in the hot seat—a therapeutic target common to many neurological disorders?”

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Post-Bacc Application Deadline
June 5, 2013

Application deadline: July 1, 2013

July 1, 2013 at midnight is the official deadline for submitting applications for the MS in Medical Physiology Program (Post-Bacc Program). Any online applications that have been initiated at that time will be considered even if it takes the applicant a week or so to complete the application (ex. provide your official transcript, provide GRE, MCAT, or DAT scores, provide your personal statement, provide 3 letters of recommendation).  The admissions committee will review your application once it is complete and all application materials are received.  If you have any questions, please contact Dr. Nosek (Thomas.Nosek@Case.edu, 216-368-3242). Contact us if you need assistance.  

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Department to Host Open House
June 1, 2013 10:30 a.m.

The Deparment has scheduled an Open House for June 1stProspective students can hear all about our educational programs, tour the CWRU campus and department laboratories, and meet faculty and students.

The application deadline for the Post-Bacc MS program is July 1, 2013.

 

 

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2013 SURP Participants
May 28, 2013 - Aug. 2, 2013

The 2013 Summer Undergraduate Research Program Participants pictured with the SURP Program Director Andrea Romani.

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Dr. Julian Stelzer Awarded First NIH R01 grant
Feb. 1, 2013

Congratulations to Dr. Julian Stelzer on the occasion of his award of an NIH RO1 grant, effective February 1, 2013, for research in the “Functional consequences of FHC mutations in cardiac MyBPC”

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Congratulations to Seong-Ki Lee on the Acceptance of Two Manuscripts
Jan. 1, 2013

 

“Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbits” Lee, S.-K., Boron, W.F., and Parker, M.D. American Journal of Physiology, 2013 (in press)

“Monitoring Ion Activities In and Around Cells Using Ion-Selective Liquid-Membrane Microelectrodes” Lee, S.-K., Boron, W.F., and Parker, M.D. Sensors, 2013 (in press)

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2012 Holiday Party
Dec. 14, 2012 3 p.m. - 6:30 p.m.

The Department hosts a Holiday Party each December to celebrate all the diverse holidays observed by our department members.

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Department Welcomes Jeff Garvin
Nov. 28, 2012

The Department welcomes Jeff Garvin, who joined us November 28, 2012. He brought with him four members of his laboratory from Henry Ford Hospital in Detroit where he was Division Head of Hypertension and Vascular Research in the Department of Internal Medicine. Jeff is an authority on epithelia transport and the role of the kidneys in the regulation of blood pressure and the genesis of hypertension. In 2011, Jeff was the recipient of the prestigious Gottschalk Award of the American Physiological Society-one of the most prestigious honors in the renal field. He has authored more than 135 publications in peer-reviewed journals and has served on numerous NIH study sections. At present Jeff leads three NIH-funded projects. He serves as Associate Editor of the American Journal of Physiology: Renal Physiology, Editor of Comprehensive Physiology: Renal Physiology and a Regular Member of the Kidney Molecular Biology and Genitourinary Organ Development study section at the NIH.

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2012 Department Retreat
Oct. 5, 2012 9 a.m.

The Department has sponsored a retreat since 1997. This retreat includes informal scientific presentations by principal investigators, students, and post-doctoral fellows, as well as a variety of social functions. This year's retreat will be held at One Cleveland Center in downtown Cleveland.  Contact Jean Davis or Morley Schwebel for more details.

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Welcome Yinghua Chen
Oct. 1, 2012

The department welcomes Yinghua Chen, who became our Core Facilities Manager on Oct 1st. She received her Ph.D. degree from the University of Alabama in 2009 and then did a postdoctoral fellowship at National Cancer Institute (NCI/NIH) in Bethesda. Her research focus at the NIH was on protein structure determination and protein-protein interactions. Yinghua is the Department’s first Core Facilities Manager, a position that we recently created to organize, streamline, and enhance operations of the Department’s cores and common-usage equipment. These cores include the Protein Expression Purification and Crystallization Core (PEPCC) on the 5th floor of Robbins, as well as the Molecular Biophysics Core on the 6th floor. Her desk will be in the PEPCC.

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Department Welcomes Jeff Garvin
Sept. 28, 2012

The Department welcomes Jeff Garvin,who will join us, effective November 28. He brings with him five members of his laboratory from Detroit. Jeff is an authority on the role of the kidneys in the regulation of blood pressure and the genesis of hypertension. In 2011, Jeff was the recipient of the prestigious Gottschalk Award of the American Physiological Society—one of the most prestigious honors in the renal field.

Jeff is currently Division Head, Hypertension and Vascular Research Division, Department of Internal Medicine, at the Henry Ford Hospital in Detroit. He also is Professor of Physiology at Wayne State University, and is currently the Principal Investigator of a Program Project Grant on hypertension from the NIH Heart, Lung, and Blood Institute.

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Phanindra Velisetty, Sreevatsa V. Chalamalasetti, & Sudha Chakrapani Publish in Journal of Biological Chemistry
Sept. 13, 2012

Congratulations on the publishing of “Conformational transitions underlying pore opening and desensitization in membrane-embedded GLIC”

In Journal of Biological Chemistry

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Congratulations to Prattana (Nat) Samasilp on the acceptance of her first manuscript.
Aug. 1, 2012

 “Activity-Dependent Fusion Pore Expansion Regulated by Calcineurin-Dependent Dynamin-Syndapin Pathway in Mouse Adrenal Chromaffin Cells."

Prattana (Nat) Samasilp, Shyue-An Chan, and Corey Smith

The Journal of Neuroscience

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Award of an NIH R01 Grant to Corey Smith
Aug. 1, 2012 noon

“Molecular Control of Differential Peptide Transmitter Exocytosis”

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Sudha Chakrapani, Ph.D. Awarded American Heart Association Scientist Development Grant
July 1, 2012 noon

Congratulations! Sudha Chakrapani, Ph.D. has been awarded a four year American Heart Association Scientist Development Grant, effective July 1, 2012.

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Krekwit Shinlapawittayatorn is recognized for Outstanding Research Scholarship
May 30, 2012 noon

2012 Doctoral Excellence Award Winner

Krekwit Shinlapawittayatorn who served in Isabelle Deschenes lab while earning his Ph.D. has been recognized for Outstanding Research Scholarship of a PhD Graduate from the Office of Graduate Education

 

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Congratulations to Jackie Hill on the acceptance of her second manuscript
May 16, 2012 noon

"Pituitary Adenylate Cyclase-Activating Peptide (PACAP) Enhances Electrical Coupling in the Mouse Adrenal Medulla.“

Jacqueline Hill, Seong-Ki Lee, Prattana Samasilp, and Corey Smith

American Journal of Physiology – Cell Physiology

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Phanindra Velisetty Published on JBC Papers in Press
April 3, 2012 noon

“Desensitization Mechanism in a Prokaryotic Ligand-Gated Ion Channel”

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Epilepsy Foundation Award for Tingwei Mu
April 2, 2012 noon Read More >

Prattana Samasilp wins "Student Achievement Award"
March 17, 2012 noon Read More >

The Journal of Physiology Paper Published
March 15, 2012 noon

HC03 – independent conductance with a mutant Na / HCO3 cotransporter (SLC4A4) in a case of proximal renal tubular acidosis with hypokalemic paralysis

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Xin Qi, Ph.D. American Heart Association Beginning Grant-In-Aid 2 Years
Jan. 27, 2012 noon Read More >

Dr. Mark Parker Awarded R21 Grant Funding from the National Eye Institute
Dec. 7, 2011 noon Read More >

2011 Department Retreat
Nov. 3, 2011 noon

The Department has sponsored a biannual offsite retreat since 1997. This retreat includes two days and evenings of informal scientific presentations by principal investigators, students, and post-doctoral fellows, as well as a variety of social functions. The next retreat will be held on Nov. 3 - 5, 2011, at Geneva Conference Center, Geneva, OH (45 minutes east of Cleveland). Contact Jean Davis or Morley Schwebel for details

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Patrick Wintrode Farewell Party
Oct. 27, 2011 3 p.m. Read More >

Matthias Buck elected to editorial board of JBC
Oct. 17, 2011 noon

Matthias Buck elected to editorial board of Journal of Biological Chemistry (JBC)

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2011 Department Picnic
July 22, 2011 3 a.m.

Squire Valleevue Farms, Area 3

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Annual Holiday Party
Dec. 17, 2010 3 p.m. Read More >

Reception to Welcome Our New Faculty
Nov. 10, 2010 3 p.m. Read More >

11th Annual DPB Retreat
Oct. 8, 2010 9 a.m.

One Cleveland Center is located at 1375 East 9th Street.

 

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