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Welcome to the Department of Physiology and Biophysics!

Welcome to the Department of Physiology and Biophysics! We are over 460 faculty, fellows, students, and staff. Building on strong traditions, we strive to be a world leader in our parallel missions of research, teaching, and service. Our founding chair John Macleod was a future Nobel Laureate, Corneille Heymans was another laureate trained in the Department, and a Lasker Award winner Carl J. Wiggers chaired the Department for a generation. Our research mission benefits from a rare combination of faculty who address important translational problems in physiology and biophysics across a broad spectrum of integration—from the level of the atomic structure of molecules, through living cells and organ systems, and up to the whole organism. The major programmatic foci of our research are cardiovascular, renal, and neuronal function in health and disease. Our educational mission includes a strong PhD-training program as well as a new Master’s program in medical physiology that has attracted considerable interest. Our service mission has a strong impact at the local, national, and international levels.

  • Mission: research, education, service
  • Research Interest: integration of physiology and biophysics from atom to whole organism
  • Former President of FASEB, Secretary General of the IUPS, Co-director of Case’s MSTP
  • Co-home to textbook Medical Physiology

Congratulations to Dr. Tingwei Mu !

Feb. 16, 2018

Dr. Mu received a 4.0 percentile rating on his NIH RO1 research proposal, “Understanding GABAA receptor protein folding and misfolding.”


March 19, 2018 4 p.m.

Mark A. Knepper, M.D., Ph.D. of the National Heart, Lung, and Blood Institute of NIH will give the 6th Annual Ulrich Hopfer Lecture on Monday, March 19, 2018 at 4:00 in SOM E-501, hosted by Dr. Walter Boron and Dr. Ulrich Hopfer.

The title of Dr. Knepper's lecture is “Regulation of Aqp2 gene expression by vasopressin."

Dr. Knepper will also meet with facutly members during his visit and a reception in his honor will be held prior to the lecture in the Department 5th floor lobby.

The Department of Physiology and Biophysics hosts the Hopfer lecture each Spring to honor Professor Emeritus Ulrich Hopfer, M.D., Ph.D. (photo)

Open House for Post-Bacc Medical Physiology Program

April 7, 2018 10 a.m. - 4 p.m.

The Department will hold an Open House for all students, parents, and undergraduate advisors interested in learning more about the MS in Medical Physiology Post-Bacc program on Saturday, April 7, 2018.  A full day of activities is scheduled. Please register here online. A second Open House will be held on Saturday, July 14, shortly before the application deadline.

For more information:

To register for the Open House:


Post-Bacc Application Deadline

July 16, 2018

July 16th, 2018 at midnight is the official deadline for submitting applications for the MS in Medical Physiology Program (Post-Bacc Program).  The admissions committee will review your application once it is complete and all application materials are received.  If you have any questions, please contact Dr. Nosek (, 216-368-3242). Contact us if you need assistance.

Recent News/Events

Congratulations to Dr. Sam Chai !

Jan. 19, 2018 4 p.m.

Sam Chai, a Ph.D. candidate advised by and in the lab of Dr. Isabelle Deschenes, publicly defended his doctoral dissertation on Friday, January 19, 2018 at 4:00 p.m. in SOM E-501.

Sam's dissertation is entitled "Novel Genetic Modifiers in a Monogenic Cardiac Arrhythmia."

A reception in the new Ph.D.'s honor followed the defense in the Department 5th floor bridge area.

Congratulations to Dr. Sandip Basak !

Jan. 10, 2018

Sandip Basak, Ph.D., a Postdoctoral Fellow in the lab of Dr. Sudha Chakrapani, has had the manuscript "Cryo-EM structure of 5-HT3A receptor in its resting conformation" accepted for publication by Nature Communications.

Welcome to Dr. Felipe Montecinos

Jan. 2, 2018

Felipe Montecitos, Ph.D. has joined the lab of Dr. Rajesh Ramachandran as a Postdoctoral Scholar, effective January 2, 2018.

Congratulations to Dr. Sudha Chakrapani

Dec. 13, 2017

Dr. Chakrapani has been appointed to the Editorial Board of the Journal of General Physiology for the term January 1, 2018
through December 31, 2020.

Congratulations to Dr. Michael Glidden !

Dec. 12, 2017 3:30 p.m. - 4:30 p.m.

Michael Glidden (l), an M.D./Ph.D. candidate in the Medical Sciences Training Program, publicly defended his doctoral dissertation on Tuesday, December 12 at 3:00 p.m. in SOM E-501.

The title of Michael's dissertation is "Single-chain insulin analogs as ultra-stable therapeutics."

The new Ph.D. has been advised by Michael Weiss, M.D., Ph.D., M.B.A. (r), who is the Cowan-Blum Professor of Cancer Research and Professor of Biochemistry & Medicine in the Endocrine Division of the Department of Biochemistry.

We wish Michael well as he returns to the M.D. track of the program in the School of Medicine.

DPB Annual Holiday Party

Dec. 9, 2017 6:30 p.m. - 10:30 p.m.

The Department hosted its annual holiday party on Saturday, December 9 from 6:30-10:30 p.m. at the Cleveland Museum of Natural History in University Circle.

The number of attendess exceeded 300 this year, including faculty, students, staff, and special guests of the department.

A string ensemble provided music and there were two planetarium shows for the attendees.

                                                                                Catering was by Zack Bruell.

Welcome to Dr. Arvind Kumar

Dec. 1, 2017

Arvind Kumar, Ph.D. has joined the lab of Dr. Sudha Chakrapani as a Postdoctoral Scholar, effective December 1, 2017.

Congratulations to Dr. Mausita Karmakar...

Nov. 22, 2017

who is one of only three travel grant awardees for the 2018 Keystone Symposium on Cell Death, Inflammation & Adaptation to Tissue Stess to be held at the Beaver Run Resort in Breckenridge, Colorado, January 21-25.

Based on her abstract submission, Dr. Karmakar has also been chosen to give an oral presentation at the symposium.

Congratulations to Amday Wolde

Nov. 17, 2017

Amday, a second year student in the combined Master's in Medical Physiology/M.B.A. program, received first prize with his team in the Cleveland Clinic Solutions’ mini case competition held in October.

Amday's team took on the challenge of improving the Cleveland Clinic’s Weight Management Program. As a result of the team’s presentation, the Clinic plans to move forward with one of the ideas in the team’s model regarding a wellness program involving cooking.


Congratulations to Dr. Xin Qi

Nov. 9, 2017

Dr. Qi has received a one-year Falk Medical Research Trust Catalyst Award for research regarding "Identification of Enhancers of Mitochondrial Function as Candidate Therapeutics of Huntington's Disease,“ effective November 30, 2017

2017 Department Retreat

Oct. 19, 2017 - Oct. 20, 2017

The Department of Physiology and Biophysics held its annual retreat at the Kalahari Resort in Sandusky, OH on Thursday and Friday, October 19 and 20, 2017.

3rd Annual Matthew Levy Lecture

Sept. 28, 2017 3 p.m.

The Department hosted the 3rd Annual Matthew N. Levy Lecture on Thursday, September 28, 2017 at 3:00 p.m. in SOM E-501.

The lecture was given by Jeanne Nerbonne, Ph.D., an Alumni Endowed Professor of Molecular Biology and Pharmacology in Medicine and Developmental Biology, the Director of the Center for Cardiovascular Research, and the Co-Director of the Center for the Investigation of Membrane Excitability Diseases at the Washington University School of Medicine in St. Louis.

The title of Dr. Nerbonne's lecture was "Diversity of Cardiac Ion Channel Regulatory Mechanisms.”

A pre-lecture reception for Dr. Nerbonne was held in the Department lobby, and our Chair, Dr. Walter Boron, presented Dr. Nerbonne with an engraved plaque after the lecture to commemorate her presentation.

The late Dr. Matthew Levy was a gifted, dedicated teacher and scientist who influenced countless students, conducted groundbreaking research on heart function and its relationship to the autonomic nervous system, and who co-authored one of the most influential texts on physiology. Each autumn, beginning with a daylong symposium in 2014, the Department honors the memory of Dr. Levy and his accomplishments.

2017 Recknagel Symposium

Sept. 13, 2017 9 a.m.

The Department of Physiology and Biophysics held its annual Recknagel Symposium on Thursday, September 13, 2017 at 9:00 a.m. in the Department lecture hall.

Two of the Department's second year doctoral students, Sheng Gong (l) and Yutong Shang (r) presented on projects from their first year laboratory rotations. Yutong Shang received the award for the best presentation and Sheng Gong received the award for academic achievement. Sheng is a member of the lab of Dr. Christopher Ford and Yutong is a member of the lab of Dr. Xin Qi.

The Department established the annual Recknagel Symposium in memory of Professor Richard Recknagel, who was Chairman of the Department of Physiology from 1976 to 1986 and an admired thinker and investigator who took a keen interest in mentoring young students and faculty.

Congratulations to Dr. Stephan Nieuwoudt !

Sept. 1, 2017 4 p.m.

Stephan Nieuwoudt, a Ph.D. candidate mentored by and in the lab of Dr. John Kirwan at the Lerner Research Institute of the Cleveland Clinic Foundation, publicly defended his doctoral dissertation on Friday, September 1, 2017 at 4:00 p.m. in SOM E-501.

The title of Stephan's dissertation is, "Insights into the Functional Roles of Exercise in Type 2 Diabetes Using In Vitro Models."

A reception was held after the defense at 5:00 p.m. in the Department's 5th floor bridge area in honor of the newly minted Ph.D.

Welcome to Dr. Nikhil Bharambe

Sept. 1, 2017

Nikhil Bharambe, Ph.D. has joined the lab of Dr. Rajesh Ramachandran as a Postdoctoral Scholar, effective September 1, 2017.

Welcome to Jake Popple

Aug. 28, 2017

Jacob Popple. B.S., a student in the Department's Master of Science in Medical Physiology program, has joined the lab of Dr. Walter Boron as a Research Assistant, effective August 28, 2017.