Welcome to the Department of Physiology and Biophysics!
Welcome to the Department of Physiology and Biophysics! We are over 460 faculty, fellows, students, and staff. Building on strong traditions, we strive to be a world leader in our parallel missions of research, teaching, and service. Our founding chair John Macleod was a future Nobel Laureate, Corneille Heymans was another laureate trained in the Department, and a Lasker Award winner Carl J. Wiggers chaired the Department for a generation. Our research mission benefits from a rare combination of faculty who address important translational problems in physiology and biophysics across a broad spectrum of integration—from the level of the atomic structure of molecules, through living cells and organ systems, and up to the whole organism. The major programmatic foci of our research are cardiovascular, renal, and neuronal function in health and disease. Our educational mission includes a strong PhD-training program as well as a new Master’s program in medical physiology that has attracted considerable interest. Our service mission has a strong impact at the local, national, and international levels.
- Mission: research, education, service
- Research Interest: integration of physiology and biophysics from atom to whole organism
- Former President of FASEB, Secretary General of the IUPS, Co-director of Case’s MSTP
- Co-home to textbook Medical Physiology
Congratulations to Dr. Pam Sangwung
July 6, 2017
Panjamaporn (Pam) Sangwung publicly defended her doctoral dissertation on Thursday, July 6, 2017 at 3:00 p.m. in SOM E-501.
The title of Pam's dissertation is "Kruppel-Like Transcription Factors: Master Regulators of Vascular Endothelium."
Pam's mentor is Mukesh K. Jain, M.D. (pictured with her)
A reception in Pam's honor was held following the defense at 4:15 p.m. in the Department's 5th floor bridge area.
Special DPB Seminar
July 5, 2017
The Department hosted a special seminar presented by Michael Decker, Ph.D., R.N., R.R.M., Diplomate A.B.S.M, an Associate Professor at the Case Western Reserve University Frances Payne Bolton School of Nursing, on Wednesday, July 5, 2017 at 4:00 p.m. in SOM E-501.
The title of Dr. Decker's seminar was "Mechanisms through which hypoxia-induced dopamine dysfunction could enhance vulnerability for substance misuse."
Dr. Decker is also a Principal Investigator and the Laboratory Director in the Bolton School of Nursing Neuroscience Lab.
Welcome to Dr. Jamie Prezioso
June 26, 2017
Jamie Prezioso, Ph.D. joined the lab of Dr. Walter Boron as a Postdoctoral Scholar/Mathematician on June 26, 2017.
Congratulations to Dr. Rajesh Ramachandran
June 27, 2017
Rajesh Ramachandran, Ph.D., an Assistant Professor in the Department of Physiology and Biophysics, has been awarded, for a term of 5 years, an R01 grant by the National Institutes of Health for research on "Molecular mechanisms of dynamin-related protein 1-mediated mitochondrial fission."
Annual Department Summer Picnic
Aug. 10, 2017
The Department will host its annual summer picnic for our associates, their family members, and significant others on Thursday, August 10, 2017 from 3:00 - 7:00 p.m. at the Cleveland Botanical Garden in University Circle.
Catering will be by Bon Appétit.
Annual DPB Baseball Outing
Aug. 25, 2017
The Department will host its annual baseball outing on Friday, August 25, when the Cleveland Indians will play the Kansas City Royals at Progressive Field downtown at 7:10 p.m.
We host the baseball outing at the beginning of each new academic year to welcome our new students and to provide an enjoyable evening for returning students, faculty, and staff. Tickets are complimentary for our students and department associates, and all include club privileges.
Image: Annie O'Neill
Congratulations to the LaManna Lab...
Feb. 8, 2017
on the publication of the manuscript, "Gender differences in hypoxic acclimatization in cyclooxygenase-2 deficient mice."
Xu K, Sun X, Benderro GF, Tsipis CP, LaManna JC. Physiol Rep. 2017 Feb;5(4). pii: e13148. doi: 10.14814/phy2.13148. Epub 2017 Feb 27.
3rd Annual Matthew Levy Lecture
Sept. 28, 2017
The Department will host the 3rd Annual Matthew N. Levy Lecture on Thursday, September 28, 2017 at 4:00 p.m. in SOM E-501.
The lecture will be given by Jeanne Nerbonne, Ph.D., an Alumni Endowed Professor of Molecular Biology and Pharmacology in Medicine and Developmental Biology, the Director of the Center for Cardiovascular Research, and the Co-Director of the Center for the Investigation of Membrane Excitability Diseases at the Washington University School of Medicine in St. Louis.
The title of Dr. Nerbonne's lecture will be “Diversity of Cardiac Ion Channel Regulatory Mechanisms.”
The late Dr. Matthew Levy was a gifted, dedicated teacher and scientist who influenced countless students, conducted groundbreaking research on heart function and its relationship to the autonomic nervous system, and who co-authored one of the most influential texts on physiology. Each autumn, beginning with a daylong symposium in 2014, the Department honors the memory of Dr. Levy and his accomplishments.
Congratulations to Dr. Xin Qi
July 1, 2017
Xin Qi, Ph.D. has been promoted to Associate Professor, with tenure, in the Department of Physiology and Biophysics, effective July 1, 2017.
Congratulations to Dr. Chris Ford
July 1, 2017
Christopher P. Ford, Ph.D. has been promoted to Associate Professor, with tenure, in the Department of Physiology and Biophysics, effective July 1, 2017.
Congratulations to Dr. Sudha Chakrapani
July 1, 2017
Sudha Chakrapani, Ph.D. has been promoted to Associate Professor, with tenure, in the Department of Physiology and Biophysics, effective July 1, 2017.
Congratulations to C. W. Gallagher...
June 19, 2017
on his award of a Summer Student Fellowship grant by the organization Fight for Sight.
C.W. is a student in the Master's in Medical Physiology program.
Open House for Post-Bacc Medical Physiology Program
June 3, 2017
The Department hosted an Open House on Saturday, June 3, 2017. Prospective received information about our educational programs, toured the CWRU campus and department laboratories, and met faculty and students.
For more information: https://physiology.case.edu/education/department-open-house/
Congratulations to Dr. Pamela Marcott!
June 2, 2017
Pamela Marcott, an M.D./Ph.D. candidate in the Medical Science Training Program (MSTP), mentored by and in the lab of Dr. Chris Ford, publicly defended her doctoral dissertation at 3:00 p.m. on Friday, June 2, 2017 in SOM E-501.
The title of Dr. Marcott's dissertation is "Mechanisms of dopamine D2-receptor activation across the striatum."
A reception in Pam's honor was held followng the defense.
Congratulations to Dr. Sandip Basak...
June 2, 2017
on his American Heart Association AWRP Winter 2017 Postdoctoral Fellowship two-year award* for the project “Effects of cholesterol and polyunsaturated fatty acids on ligand-gated ion channel structure and function,” effective July 1, 2017. Dr. Basak is a Postdoctoral Fellow in the lab of Dr. Sudha Chakrapani.
*Percentile Rank: 0.15%
Congratulations to our M.S.M.P. graduates!
May 21, 2017
Eighty-nine students in the Department's Master of Science in Medical Physiology program were awarded M.S. degrees on Sunday, May 21.
These were in addition to eighteen students in the program who graduated in December 2016.
Eight of the degrees awarded on Sunday were for the joint M.S./M.B.A. program.
Best wishes to our graduates as they begin the next stage of their lives!
Congratulations to Dr. Jeff Garvin
May 3, 2017
Dr. Garvin received the 2017 J. Bruce Jackson M.D. Award for Excellence in Undergraduate Mentoring. The award, which is in the form of an apple, was presented to Dr. Garvin by University President Barbara Snyder on May 3, 2017.
4th Annual M.S.M.P. Cardigan Day
April 20, 2017
In 2013, the Master of Science in Medical Physiology first year students conspired to all come to morning lecture wearing cardigan sweaters. The lecturer for that day, Dr. Tom Nosek, a regular wearer of cardigan sweaters "since birth", didn't notice that everyone was wearing one until it was pointed out to him.
Every Spring since, Dr. Nosek proclaims a "Cardigan Day" for the first year M.S.M.P. students and asks them to wear a cardigan to lecture. Today was that day for the class entering in Fall 2016.
Congratulations to Dr. Drew Nassal !
March 31, 2017
Drew Nassal, a Ph.D. candidate advised by and in the lab of Dr. Isabelle Deschenes, publicly defended his doctoral dissertation on Friday, March 31 at 3:00 p.m. in SOM E-501.
Dr. Nassal's dissertation is entitled "Evaluating Non-canonical Roles of KChIP2 in the Heart."
A reception for Dr. Nassal and his family followed the defense in the Department of Physiology and Biophysics 5th floor bridge area.
5th Annual Ulrich Hopfer Lecture
March 22, 2017
Dr. Amira Klip, a Senior Scientist in the Cell Biology Program at the Hospital for Sick Childen in Toronto and a professor in the Departments of Pediatrics, Biochemistry, and Physiology at the University of Toronto, gave the 5th annual Ulrich Hopfer lecture, hosted by Dr. Walter Boron and Dr. Ulrich Hopfer and the Department of Physiology and Biophysics, on Wednesday, March 22, 2017 at 4:00 p.m in SOM E-501.
The title of Dr. Klip's lecture was "Insulin and exercise signals mobilizing glucose transporters in muscle cells."
The Department hosts the Hopfer lecture each Spring to honor Professor Emeritus Ulrich Hopfer, M.D., Ph.D.
Congratulations to the Stelzer Lab...
March 10, 2017
...on the publication of their cardiac muscle research, entitled “Cardiac myosin binding protein-C Ser302 phosphorylation regulates cardiac β-adrenergic reserve.”
Science Advances,10 Mar 2017: Vol. 3, no. 3, e1602445, DOI: 10.1126/sciadv.1602445
Ranganath Mamidi*, Kenneth S. Gresham*, Jiayang Li, and Julian E. Stelzer
Congratulations to Dr. Jeff Garvin and Casandra Monzon...
March 8, 2017
on the publication of the manuscript "Nitric Oxide Reduces Paracellular Resistance in Rat Thick Ascending Limbs by Increasing Na+ and Cl- Permeabilities."
Monzon CM, Occhipinti R, Pignataro OP, Garvin JL
Am J Physiol Renal Physiol. 2017 Mar 8:ajprenal.00671.2016. doi: 10.1152/ajprenal.00671.2016. [Epub ahead of print]
Congratulations to the Chakrapani Lab...
March 6, 2017
...on the acceptance of the manuscript, "Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel" by eLife.
Sandip Basak*, Nicolaus Schmandt*, Yvonne Gicheru*, and Sudha Chakrapani
Congratulations to Rajesh Ramachandran, Ph.D.
March 1, 2017
Dr. Ramachandran received an R21 award from the National Institute for Neurological Diseases and Stroke for research on Molecular Mechanisms of Rapid Synaptic Vesicle Endocytosis..
The award period is March 1, 2017 - February 28, 2019
Congratulations to Joseph C. LaManna, Ph.D.
Feb. 27, 2017
Dr. LaManna has been elected a Fellow of the American Association of Anatomists.
Congratulations to Dr. Matthias Buck...
Feb. 8, 2017
on the publication of "Molecular Dynamics Simulations Reveal Isoform Specific Contact Dynamics between the Plexin Rho GTPase Binding Domain (RBD) and Small Rho GTPases Rac1 and Rnd1."
Zhang L, Buck M
J Phys Chem B. 2017 Feb 23;121(7):1485-1498. doi: 10.1021/acs.jpcb.6b11022. Epub 2017 Feb 8.
Liqun Zhang, Ph.D. was formerly a postdoctoral scholar in Dr. Buck's lab.