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Welcome to the Department of Physiology and Biophysics!

Welcome to the Department of Physiology and Biophysics! We are over 460 faculty, fellows, students, and staff. Building on strong traditions, we strive to be a world leader in our parallel missions of research, teaching, and service. Our founding chair John Macleod was a future Nobel Laureate, Corneille Heymans was another laureate trained in the Department, and a Lasker Award winner Carl J. Wiggers chaired the Department for a generation. Our research mission benefits from a rare combination of faculty who address important translational problems in physiology and biophysics across a broad spectrum of integration—from the level of the atomic structure of molecules, through living cells and organ systems, and up to the whole organism. The major programmatic foci of our research are cardiovascular, renal, and neuronal function in health and disease. Our educational mission includes a strong PhD-training program as well as a new Master’s program in medical physiology that has attracted considerable interest. Our service mission has a strong impact at the local, national, and international levels.

  • Mission: research, education, service
  • Research Interest: integration of physiology and biophysics from atom to whole organism
  • Former President of FASEB, Secretary General of the IUPS, Co-director of Case’s MSTP
  • Co-home to textbook Medical Physiology


May 31, 2018 4 p.m.

Amrita Samanta, a Ph.D. candidate who is mentored by Dr. Vera Moiseenkova-Bell, will publicly defend her doctoral dissertation on Thursday, May 31, 2018 at 4:00 p.m. in SOM E-501.

The title of Amrita's dissertation is "Understanding the Molecular Mechanism of TRP channel activation/inhibition by structural analysis."

A reception in the new Dr. Samanta's honor will be held following the defense at 5:00 p.m. in the Department's 5th floor bridge area.


June 5, 2018 4 p.m.

David Litivin, a Ph.D. candidate mentored by Frank Jacono, M.D., will publicly defense his doctoral dissertation at 4:00 p.m. on Tuesday, June 5, 2018 in SOM E-501.

David's dissertation is entitled "Immune-to-Brain Communication Driven by Sterile Lung Injury."

A reception in the new Dr. Litvin's honor will be held following the defense at 5:00 p.m. in the Department's fifth floor bridge area.

Open House for Post-Bacc Medical Physiology Program

June 23, 2018 10 a.m. - 4 p.m.

The Department will hold an Open House for all students, parents, and undergraduate advisors interested in learning more about the MS in Medical Physiology Post-Bacc program on Saturday, June 23, 2018.  A full day of activities is scheduled. Please register here online.

For more information:

To register for the Open House:

Post-Bacc Application Deadline

July 16, 2018

July 16th, 2018 at midnight is the official deadline for submitting applications for the MS in Medical Physiology Program (Post-Bacc Program).  The admissions committee will review your application once it is complete and all application materials are received.  If you have any questions, please contact Dr. Nosek (, 216-368-3242). Contact us if you need assistance.

Upcoming News/Events

Recent News/Events

Congratulations to Dr. Peyvand Amini

May 7, 2018 4 p.m.

Peyvand Amini, who was mentored by and a member of the lab of Dr. Sam Mesiano in the Department of Reproductive Biology, publicly defended her doctoral dissertation on Monday, May 7, 2018 at 4:00 p.m. in SOM E-501.

The title of Peyvand's dissertation is "Mechanisms by which progesterone controls human pregnancy and parturition."

A reception in Dr. Amini's honor was held at 5:00 p.m. in the Department's 5th floor bridge area.

Frontiers in Biological Sciences Lecture

April 18, 2018 4 p.m.

Dr. Walter Boron and the Department of Physiology and Biophysics hosted Dr. Peter Hunter of the University of Auckland for a School of Medicine Frontiers in Biological Sciences Lecture on Wednesday, April 18, 2018 at 4:00 p.m. in SOM E-501.

The title of Dr. Hunter's Frontiers Lecture was “Cardiac research at the Auckland Bioengineering Institute.”

Dr. Hunter is a Distinguished Professor of Engineering Science and the Director of the Auckland Bioengineering Institute at the University of Auckland (New Zealand).

A reception was held in Dr. Hunter's honor at 3:30 p.m. in the Department fifth floor lobby.

In addition, Dr. Hunter also gave a technical talk, “A mathematical physics and computer science framework for reproducible multiscale modelling in physiology”, on Thursday, April 19, 2018 at 4:00 p.m. in SOM E-501.

Congratulations to David Litvin

March 27, 2018

David Litvin, a Ph.D. candidate mentored by Frank Jacono, M.D., has had his first paper accepted by Brain, Behavior and Immunity.

The title of David's paper is "Lung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal rats."

(David G Litvin, Thomas E Dick, Corey B Smith, Frank J

                                                                                 Jacono, Brain, Behavior, and Immunity 2018 March 27)


March 19, 2018 4 p.m.


Mark A. Knepper, M.D., Ph.D. of the National Heart, Lung, and Blood Institute of NIH gave the 6th Annual Ulrich Hopfer Lecture on Monday, March 19, 2018 at 4:00 in SOM E-501, hosted by Dr. Walter Boron and Dr. Ulrich Hopfer.

The title of Dr. Knepper's lecture was “Regulation of Aqp2 gene expression by vasopressin."

Dr. Knepper also met with facutly members during his visit and a reception in his honor was held prior to the lecture in the Department 5th floor lobby.

The Department of Physiology and Biophysics hosts the Hopfer lecture each Spring to honor Professor Emeritus Ulrich Hopfer, M.D., Ph.D.

(Photo: Walter Boron, M.D., Ph.D., Mark Knepper, M.D., Ph.D., Ulrich Hopfer, M.D., Ph.D.)

Congratulations to Dr. Tingwei Mu

Feb. 16, 2018

Dr. Mu received a 4.0 percentile rating on his NIH RO1 research proposal, “Understanding GABAA receptor protein folding and misfolding.”

Congratulations to Dr. Sam Chai

Jan. 19, 2018 4 p.m.

Sam Chai, a Ph.D. candidate advised by and in the lab of Dr. Isabelle Deschenes, publicly defended his doctoral dissertation on Friday, January 19, 2018 at 4:00 p.m. in SOM E-501.

Sam's dissertation is entitled "Novel Genetic Modifiers in a Monogenic Cardiac Arrhythmia."

A reception in the new Ph.D.'s honor followed the defense in the Department 5th floor bridge area.

Congratulations to Dr. Sandip Basak

Jan. 10, 2018

Sandip Basak, Ph.D., a Postdoctoral Fellow in the lab of Dr. Sudha Chakrapani, has had the manuscript "Cryo-EM structure of 5-HT3A receptor in its resting conformation" accepted for publication by Nature Communications.

Welcome to Dr. Felipe Montecinos

Jan. 2, 2018

Felipe Montecitos, Ph.D. has joined the lab of Dr. Rajesh Ramachandran as a Postdoctoral Scholar, effective January 2, 2018.

Congratulations to Dr. Sudha Chakrapani

Dec. 13, 2017

Dr. Chakrapani has been appointed to the Editorial Board of the Journal of General Physiology for the term January 1, 2018
through December 31, 2020.

Congratulations to Dr. Michael Glidden

Dec. 12, 2017 3:30 p.m. - 4:30 p.m.

Michael Glidden (l), an M.D./Ph.D. candidate in the Medical Sciences Training Program, publicly defended his doctoral dissertation on Tuesday, December 12 at 3:00 p.m. in SOM E-501.

The title of Michael's dissertation is "Single-chain insulin analogs as ultra-stable therapeutics."

The new Ph.D. has been advised by Michael Weiss, M.D., Ph.D., M.B.A. (r), who is the Cowan-Blum Professor of Cancer Research and Professor of Biochemistry & Medicine in the Endocrine Division of the Department of Biochemistry.

We wish Michael well as he returns to the M.D. track of the program in the School of Medicine.

DPB Annual Holiday Party

Dec. 9, 2017 6:30 p.m. - 10:30 p.m.

The Department hosted its annual holiday party on Saturday, December 9 from 6:30-10:30 p.m. at the Cleveland Museum of Natural History in University Circle.

The number of attendess exceeded 300 this year, including faculty, students, staff, and special guests of the department.

A string ensemble provided music and there were two planetarium shows for the attendees.

                                                                                Catering was by Zack Bruell.

Welcome to Dr. Arvind Kumar

Dec. 1, 2017

Arvind Kumar, Ph.D. has joined the lab of Dr. Sudha Chakrapani as a Postdoctoral Scholar, effective December 1, 2017.

Congratulations to Dr. Mausita Karmakar...

Nov. 22, 2017

who is one of only three travel grant awardees for the 2018 Keystone Symposium on Cell Death, Inflammation & Adaptation to Tissue Stess to be held at the Beaver Run Resort in Breckenridge, Colorado, January 21-25.

Based on her abstract submission, Dr. Karmakar has also been chosen to give an oral presentation at the symposium.