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Jeffrey R. Schelling, MD
MD, Medicine, Case Western Reserve University
BA, Biology/Biological Sciences, Northwestern University
View Curriculum Vitae (pdf)

Mailing Address:
SOM, Robbins E611
10900 Euclid Avenue
Cleveland , OH 44106
Phone: 216-368-1100

Research Interests

The Schelling laboratory utilizes in vitro molecular and cellular methods, animal models and human samples to investigate glomerular and tubulointerstitial pathophysiology in the context of CKD, especially diabetic kidney disease. We made the initial discovery that proximal tubule cell apoptosis leads to tubular atrophy, which strongly predicts CKD progression. We have continued to build on that theme, with many publications that characterize the cellular pathways that impact on tubular epithelial cell survival, most recently the role of filtered fatty acid uptake by fatty acid transporter-2 (FATP2) in proximal tubule glucolipotoxicity. We are actively pursuing projects which explore the pathophysiology of FATP2-mediated cytotoxicity, as well as the development of FATP2 inhibitors as a potential treatment for diabetes and diabetic kidney disease. 

FATP2 Gene Deletion Rescues GFR and Hyperglycemia in Mice with Diabetic Kidney Disease

Figure 1

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