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Welcome to the Department of Physiology and Biophysics!


Welcome to the Department of Physiology and Biophysics! We are over 170 faculty, fellows, students, and staff. Building on strong traditions, we strive to be a world leader in our parallel missions of research, teaching, and service. Our founding chair John Macleod was a future Nobel Laureate, Corneille Heymans was another laureate trained in the Department, and a Lasker Award winner Carl J. Wiggers chaired the Department for a generation. Our research mission benefits from a rare combination of faculty who address important translational problems in physiology and biophysics across a broad spectrum of integration—from the level of the atomic structure of molecules, through living cells and organ systems, and up to the whole organism. The major programmatic foci of our research are cardiovascular, renal, and neuronal function in health and disease. Our educational mission includes a strong PhD-training program as well as a new Master’s program in medical physiology that has attracted considerable interest. Our service mission has a strong impact at the local, national, and international levels.

  • Mission: research, education, service
  • Research Interest: integration of physiology and biophysics from atom to whole organism
  • Former President of FASEB, Secretary General of the IUPS, Co-director of Case’s MSTP
  • Co-home to textbook Medical Physiology

Congratulations to Dr. Xin Qi...

Sept. 13, 2016

on the acceptance of the paper “Inhibition of Drp1 mitochondrial translocation provides neuronal protection in dopaminergic system in a Parkinson’s disease model induced by MPTP”

Scientific Reports, 2016 Sep 13;6:32656.

Filichia E, Hoffer B, Qi X*, Luo Y*

*co-corresponding author



2nd Annual Matthew Levy Lecture

Oct. 7, 2016 4 p.m.

The Department will host the 2nd Annual Matthew Levy Lecture on Friday, October 7, 2016 at 4:00 p.m. in Room E-501 of the School of Medicine..

The guest lecturer will be Jonathan A. Epstein, M.D., the Executive Vice Dean and Chief Scientific Officer, and the William Wikoff Smith Professor of Cardiovascular Research at the Perelman School of Medicine of the University of Pennsylvania.

Dr. Epstein's lecture is titled "Regulation of nuclear architecture drives cell fate."

A reception will be held prior to the lecture at 3:15 p.m. in the Department lobby.

The late Dr. Matthew Levy was a gifted, dedicated teacher and scientist who influenced countless students, conducted groundbreaking research on heart function and its relationship to the autonomic nervous system, and who co-authored one of the most influential texts on physiology. Each autumn, beginning with a daylong symposium in 2014, the Department honors the memory of Dr. Levy and his accomplishments.



DPB Frontiers in Biological Sciences Lecture

Oct. 19, 2016 4 p.m.

Dr. Christopher Ford and Dr. Sudha Chakrapani will host Dr. Eric Gouaux at the 2016 Department of Physiology and Biophysics Frontiers in Biological Sciences Lecture on Wednesday, October 19 at 4:00 p.m. in SOM E-501.

Dr. Gouaux's lecture is entitled "Music of the brain illuminated by molecular studies of the instruments:  X-rays and electrons reveal architecture and mechanism of neurotransmitter receptors and transporters."

Eric Gouaux, Ph.D. is an Investigator at the Howard Hughes Medical Institute and a Senior Scientist at the Vollum Institute and holds the Jennifer and Bernard Lacroute Term Chair in Neuroscience Research at the Oregon Health & Science University.



Upcoming News/Events

Post-Bacc Application Deadline

June 19, 2017

June 19th, 2017 at midnight is the official deadline for submitting applications for the MS in Medical Physiology Program (Post-Bacc Program).  The admissions committee will review your application once it is complete and all application materials are received.  If you have any questions, please contact Dr. Nosek (thomas.nosek@case.edu, 216-368-3242). Contact us if you need assistance.



Recent News/Events

2016 Department Retreat / Recknagel Symposium

Sept. 23, 2016 7:30 a.m. - 4:45 p.m.

The Department of Physiology and Biophysics held its annual retreat on Friday, September 23, 2016 at the Huntington Convention Center in downtown Cleveland.

The annual Recknagel Symposium also took place at the retreat. Three of the Department's second year doctoral students, Michael Babinchak, Yuan Cai, and Nitish Rana, presented on projects from their first year laboratory rotations. Yuan Cai won the Recknagel awards for both his presentation and for academic achievement.

The Department established the annual Recknagel Symposium in memory of Professor Richard Recknagel, who was Chairman of the Department of Physiology from 1976 to 1986 and an admired thinker and investigator who took a keen interest in mentoring young students and faculty.

 



Congratulations to Dr. Ahlam Salameh

Sept. 6, 2016 3:30 p.m.

Ahlam Salameh publicly defended her doctoral dissertation on Tuesday, September 6, 2016 at 3:30 p.m. in SOM E-501.

The title of Dr. Salameh's dissertation is "Metabolic acidosis and the mysterious role of the anion exchanger AE3 in the intracellular-pH physiology of hippocampal neurons and astrocytes".

Ahlam was advised by and in the lab of Dr. Walter Boron, the Myers/Scarpa Professor and Chair of the Department of Physiology and Biophysics.

A reception in Ahlam's honor, with her family in attendance, followed the defense at 5:00 p.m.



Annual Department Baseball Outing - Indians vs. Marlins

Sept. 2, 2016 7:10 p.m.

The Department will host its annual baseball outing on Friday, September 2 at Progressive Field in downtown Cleveland. The Cleveland Indians will play the Miami Marlins at 7:10 p.m.

Faculty, students, postdocs, and staff members may reserve a complimentary ticket with club privileges, which includes all food concessions at no cost. Additional tickets with club privileges are available for purchase at a price of $62.00 each.

The Department hosts the baseball outing at the beginning of each academic year to welcome our new Ph.D. and M.S. students.



Welcome 2016 Masters in Medical Physiology Students

Aug. 25, 2016

The department welcomed the Master’s in Medical Physiology class matriculating in 2016. These students come from 26 different states, 8 foreign countries, and 111 different colleges and universities. This is the sixth class in the MSMP program.



Congratulations to the Lab of Dr. Xin Qi...

July 22, 2016

on the acceptance of the paper “VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease” by Nature / Communications

Xing Guo, Xiaoyan Sun,  Di Hu, Yajuan Wang, Dr. Hisashi Fujioka, Rajan Vyas, Sudha Chakrapani, Amit Joshi, Yu Luo and Xin Qi.



Congratulations to Hana Russo...

July 6, 2016

...on the acceptance of the paper as first author, based on her dissertation research,

“Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides”

Hana M. Russo,  Joseph Rathkey,  Andrea Boyd-Tressler,  Michael A. Katsnelson,  Derek W. Abbott,  and George R. Dubyak.

J Immunol 1600699; published ahead of print July 6, 2016, doi:10.4049/jimmunol.1600699

Hana, a student in the Medical Scientist Training Program, is a Ph.D. candidate in Pathology in the lab of Dr. George Dubyak.

Andrea Boyd-Tressler, a Ph.D. graduate of the Dubyak lab in Pharmacology, has begun her 1st year as an M.D. candidate at the Lerner Cleveland Clinic College of Medicine of CWRU.

Michael Katsnelson, a student of the Medical Scientist Training Program and a Ph.D graduate of the Dubyak lab in Pathology, is currently completing his final year as an M.D. candidate at the Case School of Medicine.



Congratulations to Ahlam Salameh

July 5, 2016

Ahlam, a Ph.D. candidate in the lab of Dr. Walter Boron, has had a Perspectives editorial article to accompany her recently accepted second paper,

"Role of Cl-HCO3 exchanger AE3 in intracelllular-pH homeostatis in cultured murine hippocampal neurons, and in crosstalk to adjacent astrocytes"

commissioned by the The Journal of Physiology.

Ahlam I. Salameh, Christian A. Hübner, and Walter F. Boron. J. Physiol, June 2016



Congratulations to Dr. Julian Stelzer

July 1, 2016

Julian Stelzer, Ph.D. has been promoted to Associate Professor, effective July 1, 2016.

Dr. Stelzer joined the Department of Physiology and Biophysics as a Visiting Professor and was named an Assistant Professor in February 2009.

 



Congratulations to Dr. Ken Gresham

May 27, 2016

Ken Gresham (photo right), a Ph.D. candidate in the lab of Dr. Julian Stelzer (photo left), publicly defended his doctoral dissertation on Friday, May 27, 2016 at 2:30 p.m. in SOM E-501.

The title of Ken's dissertation is "MyBP-C Phosphorylation Regulates Ventricular Pressure Development and Relaxation."

A reception in Ken's honor catered by A Taste for Excellence followed the defense at 3:30 p.m. in the 5th floor bridge area.



Congratulations to Dr. Ranganath Mamidi

May 25, 2016

Dr. Mamidi has been awarded a two-year Postdoctoral Fellowship by the American Heart Association, effective July 1, 2016, to study "Sarcomere-based pharmacological approach to rescue contractile dysfunction in dilated and hypertrophic cardiomyopathies."

Ranga is a member of the lab of Dr. Julian Stelzer.



Congratulations to Dr. Chris Ford

May 24, 2016

Dr. Ford has been elected to serve on the NIH Molecular Neuropharmacology and Signaling (MNPS) study section for the term 2016-2020.



Congratulations to Dr. Michael Katsnelson, Kristen Lozada-Soto & Hana Russo...

May 11, 2016

...on acceptance of the paper 

"NLRP3 Inflammasome Signaling is Activated by Low-Level Lysosome Disruption but Inhibited by Extensive Lysosome Disruption: Roles  for K+ Efflux and Ca2+ Influx."

Katsnelson MA, Lozada-Soto KM, Russo HM, Miller BA, Dubyak GR. Am J Physiol Cell Physiol. 2016 May 11:ajpcell.00298.2015. doi:10.1152/ajpcell.00298.2015. [Epub ahead of print] PubMed PMID: 27170638.



Congratulations to Pam Marcott

April 27, 2016

Pam Marcott, a Ph.D. candidate in the lab of Dr. Chris Ford, was awarded a National Research Service Award Predoctoral Research Fellowship (F30) by the National Institute on Drug Abuse (NIDA) of NIH for research on "Functional properties of dopamine and glutamate cotransmission in the nucleus accumbens," effective March 8, 2016.



Congratulations to Dr. Walter Boron

April 26, 2016

Walter Boron, M.D., Ph.D., the Myers/Scarpa Professor and Chair of the Department of Physiology and Biophysics, has been awarded a five-year Multidisciplinary University Research Inititative (MURI) grant from the Office of Naval Research, effective June 1, 2016, for the research topic, "Molecular mechanisms and pathways for gas transport across biological membranes and implications for physiology and performance."

The University of Southern California and the University of Illinois at Urbana-Champaign are also participating in this research.



Congratulations to Dr. Sudha Chakrapani

April 21, 2016

Dr. Chakrapani has been elected to the Council of the Society of General Physiologists for the term 2015 - 2018.



Congratulations to Dr. Nick Courtney

April 21, 2016

Dr. Courtney, who was awarded a Ph.D. on October 30, 2015, has received a Graduate Excellence Award from the CWRU School of Graduate Studies. Nick was a member of the lab of Dr. Chris Ford and is currently a postdoctoral fellow in the lab of Dr. Edwin Chapman at the Howard Hughes Medical Institute at the University of Wisconsin - Madison.



Congratulations to Dr. Julian Stelzer

April 18, 2016

Dr. Stelzer has been awarded a BRS Shared Instrumentation Grant (S10) by the National Institutes of Health for research on "High resolution ultrasound for small animal imaging," effective May 1, 2016.



Post-Baccalaureate Program MS in Medical Physiology

PhD Program Physiology and Biophysics

Upcoming Seminars


DEPARTMENT SEMINAR

"Revealing the Structure and Function of Membrane Proteins Through Nanotechnology"

Stephen G. Sligar, PhD
Oct. 3, 2016 4 p.m. - 5 p.m.

School of Medicine E501
Hosted by: Amrita Samanta


2ND ANNUAL MATTHEW LEVY LECTURE

"Regulation of nuclear architecture drives cell fate"

Jonathan A. Epstein, MD
Oct. 7, 2016 4 p.m. - 5 p.m.

School of Medicine E501
Hosted by: Walter F. Boron, MD, PhD




Highlights

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