| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
This course is a guided program of study of physiology textbooks, reviews and original articles for CWRU undergraduate students. Guided laboratory projects to reproduce and extend classical physiological experiments are offered to the undergraduate science major. This course is being offered in conjunction with the graduate level course PHOL 451. Students are required to consult with the faculty member whose work they have interest in and plan their individual experience.
Weekly one-hour reviews by faculty or invited speakers on their research for CWRU undergraduate students.
| Patrick Osei-Owusu, PhD, FAHA | 216-368-4062 | patrick.osei-owusu@case.edu |
| Witold K. Surewicz, PhD | 216-368-0139 | witold.surewicz@case.edu |
PHOL401A/B--Physiology and Biophysics of Molecules and Cells--is a graduate-level introductory course
designed to provide the fundamental principles of modern physiology, protein science and structural biology,
and to prepare students for advanced courses in the biomedical sciences. The course is divided into 2 blocks
that can be taken independently (PHOL401A and PHOL401B; 2 credit hrs each) or sequentially during the
Spring semester of each year. The first block (401A) will cover the structure and function of proteins and
lipids, and the organization of cellular membranes. Topics will include primary, secondary, tertiary and
quarternary protein structure and analysis, enzyme kinetics, allostery and cooperativity, lipid membrane
organization and domain structure, and protein-protein and protein-lipid interactions. The second block
(401B) will cover molecular pathways and processes critical for cellular homeostasis, function, and signaling.
Topics will include molecular mechanisms of transport across biological membranes and cellular
compartments, ionic basis of the resting membrane potential, action potential generation and propagation,
regulation of voltage-gated channels and electrogenic transporters, cellular volume and pH regulation, and the
biophysics of epithelial transport.
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
Physiology is the dynamic study of life. It describes the vital functions of living organisms and how their organs and cells provide integrated interactions. Human body functions depends on how the individual organ systems function, which depends on how the component cells function, which in turn depends on the interactions among subcellular organelles, hormones, neurotransmitters, and proteins or enzymes. Understanding physiology requires an integrated understanding of interactions at the level of molecules, cells, and organs. The primary method of instruction is a combination of lectures and in-class discussions of key physiological concepts and pertinent research articles, with the intent of providing an integrated vision of how major physiological processes are controlled and integrated (e.g. regulation of blood pressure, glycemia, etc.).
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
| Jessica C. Taylor, PhD | 216-368-5745 | jessica.c.taylor@case.edu |
Physiological Basis for Disease is a graduate-level course designed to provide the fundamental physiology of a select group of organ systems and examples of how the molecular basis of disease affects physiological function of these systems. As such, PHOL402 will prepare students for future study in advanced biomedical sciences. The course is 3 credit hours and will be offered in the both the Fall (402A) and Spring (402B) semesters of each academic year. Course content of PHOL402 builds on knowledge learned in Medical Physiology-- PHOL481 and PHOL482, and is designed to be taken concurrently or in series with Medical Physiology courses. Topics to be covered during the Fall (402A) semester include pathophysiology of cancer, and select diseases of the central nervous system, cardiovascular system, and urinary/renal system. Topics to be covered in the Spring (402B) semester include select diseases of the respiratory, gastrointestinal, endocrine, and reproductive systems.
| Kui Xu, MD, PhD | 216-368-5950 | kui.xu@case.edu |
PHOL 410 is a 3-credit lecture-based graduate course and can be taken online. The course presents the significance and consequences of oxygen and oxygen metabolism in living organisms. Topics to be covered include oxygen transport by blood tissues, oxygen toxicity, and mitochondrial metabolism. Emphasis will be placed on mammalian physiology with special reference to brain oxidative metabolism and blood flow as well as whole body energy expenditure and oxidative stress related to disease. The course covers additional spans of physiology, nutrition and anatomy.
| Lisa Damato, PhD | 216-368-5634 | egd@case.edu |
| Michael J. Decker, PhD | 216-368-2467 | mjd6@case.edu |
Aerospace Physiology entails an understanding of human performance in response to the challenges of work and exploration at higher earth atmosphere and space. Human evolution over ~500,000 years built upon mammalian genetic and behavioral adjustments to earth’s atmosphere, but now includes social, cultural, and technology forces which have permitted exploration of flight above the highest successful adapted human populations at~4000m (Tibet, Andes, and Ethiopia). All the principles learned in the study of normal and disease states in these conditions apply to aerospace activities.
Introduction to Aerospace I is the first of two introductory courses to this physiology using 5 blocks clustering around concepts of cell biology, neural systems, cardiopulmonary functions, and renal adaptation. Scenarios in acute, sub-acute, and chronic responses to the challenge of the aerospace environment illustrate useful physiology and unique responses relevant to high performance aircraft and space exploration. This course is available, with the course director’s permission, to all CWRU undergraduate and graduate students.
| Lisa Damato, PhD | 216-368-5634 | egd@case.edu |
| Michael J. Decker, PhD | 216-368-2467 | mjd6@case.edu |
Aerospace Physiology entails an understanding of human performance in response to the challenges of work and exploration in at higher earth atmosphere and space. Human evolution over ~500,000 years built upon mammalian genetic and behavioral adjustments to earth’s atmosphere. Advanced practice now includes social, cultural, and technology forces in civilian and military unique transportation and flight challenges at near space and space exploration. The principles of physiology learned in the study of normal and disease states were introduced in Introduction to Aerospace Physiology I.
Introduction to Aerospace Physiology II expands on basic physiologic principles to explore 4 areas of expertise, focusing on skills as well as knowledge. Whole body effects of individual environmental challenges (acceleration, hypoxia and hyperoxia, special disorientation, radiation and thermal challenges) and methods to identify and promote resilience will be considered. Forward leaning incident investigations require appreciation of behavioral interventions, measureable and modifiable human factors, and physiologic forensics and root cause analysis.
| Lisa Damato, PhD | 216-368-5634 | egd@case.edu |
| Michael J. Decker, PhD | 216-368-2467 | mjd6@case.edu |
One semester experience in the Center for Aerospace Physiology, with Drs. Michael Decker (Instructor) and Lisa Damato (Co-Instructor) designed to introduce the student to aspects of research methods including the design, execution and analysis of original data collection of measures related to the Respiratory, Musculoskeletal, Nervous, and Cardiovascular systems relevant to Aerospace Physiology. Hands-on experiences will reinforce the strengths and limitations of current measures for human physiology.
| Walter F. Boron, MD, PhD | 216-368-8978 | walter.boron@case.edu |
| Rossana Occhipinti, PhD | None | rossana.occhipinti@case.edu |
Credit Notes:
Spring: Lecture Program (1 credit): MWF 2:00-3:30 PM for 4 weeks
Mentored Research Program (2 credits): MF 2:00-2:50 PM
This course is a graduate-level course designed to provide hands on experience in computational modeling of the neural regulation of digestive and renal epithelia through a lecture-based module and supervised modeling projects that make use of datasets, maps and models assembled and made available through the Stimulating Peripheral Activity to Relieve Conditions (SPARC) program of the National Institutes of Health (NIH). The SPARC program is a large NIH project aimed at understanding the anatomy and physiology of the autonomic nervous system (ANS) and its connections to develop new therapies based on the emerging science of neuromodulation.
The Lecture program will provide talks and small group tutorials introducing SPARC, concepts of open science, and modeling methodologies relevant to epithelial cells (including transporters & channels) and their control by the autonomic and enteric nervous systems. Students can take this first part as a 1 credit hour.
The Research program will provide students with a mentored experience in the development, testing, and textbook-linked publication of a Findable, Accessible, Interoperable, Reusable (FAIR) model that simulates epithelial transport. These models will be generated using SPARC data and models, and leveraging SPARC infrastructure. The research program is 2 credits. The Lecture program is a required pre-requisite for the Research program.
The outcome of this reproducibility project will be submitted to an online repository. Students will be given the opportunity to publish their models in the Physiome journal (or another journal that publishes computational models). Physiome is an open access journal, launched by the International Union of Physiological Sciences (IUPS) that publishes reproducible and reusable mathematical models of physiological processes, where the experimental details and model validation have been published in a recognized 'primary' peer-reviewed journal. For the FAIR DOs (‘Findable, Accessible, Interoperable, Reusable Development of Open Simulations’) educational Physiome papers, the Medical Physiology textbook by Boron & Boulpaep will be regarded as the primary publication. Dr. Peter Hunter is the Editor-in-Chief of Physiome and Dr. Walter Boron is a co-editor of Medical Physiology. Drs. Nickerson & Occhipinti are members of the Editorial Board of Physiome.
More info on the program can be found at: https://nih-sparc.github.io/FAIR-DOs
Provides students with an in-depth introduction to biophysical techniques used to quantify macromolecular structures. A major part of the course will deal with the use of nuclear magnetic resonance to derive 3-D structures of macromolecules in solution. Other topics include electron spin resonance, absorption, fluorescence and circular dichroism spetros copies, Raman and infrared spectroscopies and methods used in modeling. Taken with "Advanced Methods in Structural Biology II". This course will provide an extensive overview for graduate students specializing in structural biology. The course will be mostly lecture based. This course is cross-listed with CHEM 430, PHRM 430, and BIOC 430.
This couse is offered by the Department of Biochemistry as BIOC 434.
The Director is Paul R. Carey, PhD, please contact him with any questions.
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
For students enrolled in the Masters in Medical Physiology program, this course replaces the Masters’ thesis. The students are required to write a 20-25 page state-of-the art manuscript, on a topic of physio-pathological relevance, under the guidance of their academic advisor.
For all other graduate students, the course emphasizes faculty-directed student self-learning, utilizing physiology textbooks, research reviews, and original research articles, followed-up by discussion sessions with the faculty. This course can be taken with any of the primary or secondary faculty in the Department. A laboratory research project may also be included (1-3 credits).
| Matthias Buck | 216-368-8651 | matthias.buck@case.edu |
The goal of this course is to provide a basic working knowledge of protein structure/function and molecular biology. The course begins with a discussion of protein structure and enzyme catalysis followed by protein purification and characterization. The course then addresses concepts relating to the application of modern molecular biology techniques. Students are taught how to clone genes and use these clones in animals-and cell-based studies. The overall goal is to provide students with an understanding of proteins and genetic approaches that can be used in experimental work and to facilitate comprehension of the scientific literature. (3 credits - twice weekly- 1.5 h/lecture)
| George R. Dubyak, PhD | 216-368-5523 | george.dubyak@case.edu |
This is an advanced lecture/journal/discussion format course that covers cell signaling mechanisms. Includes are discussions of neurotransmitter-gated ion channels, growth factor receptor kinases, cytokine receptors, G protein-coupled receptors, steroid receptors, heterotrimeric G proteins, ras family GTPases, second messenger cascades, protein kinase cascades, second messenger regulation of transcription factors, microtubule-based motility, actin/myosin-based motility, signals for regulation of cell cycle, signals for regulation of apoptosis. (3 credits - twice weekly - 2 h/lecture)
The focus for this course on a special topic of interest in evolutionary biology will vary from one offering to the next. Examples of possible topics include theories of speciation, the evolution of language, the evolution of sex, evolution and biodiveristy, molecular evolution.
ANAT/ANTH/EEPS/PHIL/PHOL 467/BIOL 468 will require a longer, more sophisticated term paper, and additional class presentation.
This student-guided discussion/journal course focuses on biological membranes. Topics discussed include termodynamics and kinetics of membrane transport, oxidative phosphorylation and bioenergetics, electro-physiology of excitable membranes, and whole and single channel electrophysiology, homeostasis and pH regulation, volume and calcium regulation. (3 credits - twice weekly 1.5 h/lecture)
| Matthias Buck | 216-368-8651 | matthias.buck@case.edu |
This course focuses on in-depth understanding of the molecular biophysics of proteins. Structural, thermodynamic and kinetic aspects of protein function and structure-function relationships will considered at the advanced conceptual level. The application of these theoretical frameworks will be illustrated with examples from the literature and integration of biophysical knowledge with description at the cellular and systems level. The format consists of lectures, problems sets, and student presentations. A special emphasis will be placed on discussion of original publications. (3 credits - twice weekly)
This course focuses on a quantitative understanding of cellular processes. It is designed for students who feel comfortable with and are interested in analytical and quantitative approaches to cell biology and cell physiology. Selected topics in cellular biophysics will be covered in depth. Topics include theory of electrical and optical signal processing used in cell physiology, thermodynamics and kinetics of enzyme and transport reactions, single ion channel kinetics and excitability, mechanotransduction, and transport across polarized cell layers. The format consists of lectures, problem sets, computer simulations, and discussion of original publications. The relevant biological background of topics will be provided appropriate for non-biology science majors. (4 credits-twice weekly)
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
Physicians, like other biomedical professionals, use deductive reasoning with multiple hypotheses to solve problems. The objectives of this course are to educate students: 1) to solve clinical problems using medical physiology principles, and 2) to develop an overall accurate view of clinical reasoning and improve critical thinking skills. The didactic approach is goided discovery with problem-based learning, a common format in US medical and dental schools. The primary method of instruction is a combination of lectures, in-class discussions of key clinical concepts, and Team-Based Learning (TBL) of case studies. The topics covered in Clinical Reasoning I are cardiovascular, pulmonary, and renal diseases.
This course is complemented by Clinical Reasoning II (PHOL 492), which is offered in the spring semesters, and Clinical Reasoning III (PHOL 493), which is offered in the summer semesters. These two courses use the same teaching format to cover diseases of the gastrointestinal, endocrine, and reproductive systems (PHOL 492) and neurological, hematopoietic, and oncologic (cancer) diseases (PHOL 493). Each of the Clinical Reasoning Courses can be taken independent of the others. All three courses require the Course Director's approval and are open to graduate students in biomedical related masters programs across campus.
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
This course combines an advanced introduction to the fundamental physiological principles governing the major organ systems in mammals with discussion of major physio-pathological topics. The function of the nervous, endocrine, digestive, muscle, circulatory, respiratory, and urinary systems are discussed. The course is integrated by weekly translational classes addressing relevant biomedical topics selected in conjunction with the class.
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
This course combines an advanced introduction to the fundamental physiological principles governing the major organ systems in mammals with discussion of major physio-pathological topics. The function of the nervous, skeletal muscle, cardiac, circulatory, and respiratory systems are discussed using a highly interactive, lecture based format.
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
This course combines an advanced introduction to the fundamental physiological principles governing the major organ systems in mammals with discussion of major physio-pathological topics. The function of the digestive, urinary, endocrine, and reproductive systems are discussed using a highly interactive, lecture based format. At the conclusion of the semester, integrative aspects of major organ systems physiology will be illustrated through consideration of specific topics including exercise, high altitude physiology, pregnancy, and aging.
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
The Medical Physiology courses are prerequisites for the Translational Physiology courses (it is expected that they will be taken concurrently). The faculty coordinating a Medical Physiology block will choose the clinical cases that they think would best complement the material taught in the Medical Physiology course. A clinical faculty member will give a 45 minute presentation on this topic. The second hour of each class will be dedicated to discussing this material, often in the context of a clinical paper that the students will have been assigned to read before the class. There may also be a discussion of the clinical cases highlighted in the chapters in BandB covered that week. Students should come to class prepared to discuss these cases. The clinical faculty member will be invited to attend the second hour of the class.
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
The Medical Physiology courses are prerequisites for the Translational Physiology courses (it is expected that they will be taken concurrently). The faculty coordinating a Medical Physiology block will choose the clinical cases that they think would best complement the material taught in the Medical Physiology course. A clinical faculty member will give a 45 minute presentation on this topic. The second hour of each class will be dedicated to discussing this material, often in the context of a clinical paper that the students will have been assigned to read before the class. There may also be a discussion of the clinical cases highlighted in the chapters in BandB covered that week. Students should come to class prepared to discuss these cases. The clinical faculty member will be invited to attend the second hour of the class.
| Kui Xu, MD, PhD | 216-368-5950 | kui.xu@case.edu |
PHOL 485 is a 3-credit lecture-based graduate course and can be taken online. This course presents physiological concepts from the comparative and evolutionary perspective. Aspects of vertebrate and mammalian evolution will be considered with respect to the generation of adaptive advantages for organisms to changing environmental challenges since the Cambrian. Comparative physiological concepts include scaling, variations in nutrition, energy metabolism and work efficiency. The important influences of time, temperature, water and energy on mammalian biology will be presented.
| Jessica C. Taylor, PhD | 216-368-5745 | jessica.c.taylor@case.edu |
Physiology of Motion is coming soon.
| Jessica C. Taylor, PhD | 216-368-5745 | jessica.c.taylor@case.edu |
Exercise Physiology for Health and Disease is a graduate level course designed to provide an understanding of the fundamentals of the physiological and biochemical principles of exercise physiology and the application of these principles in health and disease. As such, PHOL 487 will prepare students for future study in advanced biomedical sciences. The course is 3 credit hours and will be offered in the both the Fall and Summer semesters of each academic year. Course content of PHOL 487 builds on knowledge learned in Medical Physiology-- PHOL 481 and PHOL 482. Topics to be covered include physiology of exercise, metabolism, and the application of exercise to select diseases of the musculoskeletal, gastrointestinal, endocrine, and cardiovascular systems.
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
Physicians, like other biomedical professionals, use deductive reasoning with multiple hypotheses to solve problems. The objectives of this course are to educate students: 1) to solve clinical problems using medical physiology principles, and 2) to develop an overall accurate view of clinical reasoning and improve critical thinking skills. The didactic approach is goided discovery with problem-based learning, a common format in US medical and dental schools. The primary method of instruction is a combination of lectures, in-class discussions of key clinical concepts, and Team-Based Learning (TBL) of case studies. The topics covered in Clinical Reasoning II are diseases of the gastrointestinal, endocrine, and reproductive systems.
This course is complemented by Clinical Reasoning I (PHOL 479), which is offered in the fall semesters, and Clinical Reasoning III (PHOL 493), which is offered in the summer semesters. These two courses use the same teaching format to cover diseases of the cardiovascular, pulmonary, and renal systems (PHOL 479) and neurological, hematopoietic, and oncologic (cancer) diseases (PHOL 493). Each of the Clinical Reasoning Courses can be taken independent of the others. All three courses require the Course Director's approval and are open to graduate students in biomedical related masters programs across campus.
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
Physicians, like other biomedical professionals, use deductive reasoning with multiple hypotheses to solve problems. The objectives of this course are to educate students: 1) to solve clinical problems using medical physiology principles, and 2) to develop an overall accurate view of clinical reasoning and improve critical thinking skills. The didactic approach is goided discovery with problem-based learning, a common format in US medical and dental schools. The primary method of instruction is a combination of lectures, in-class discussions of key clinical concepts, and Team-Based Learning (TBL) of case studies. The topics covered in Clinical Reasoning III are neurological, hemotopoietic, and oncologic (cancer) diseases.
This course is complemented by Clinical Reasoning I (PHOL 479), which is offered in the fall semesters, and Clinical Reasoning II (PHOL 492), which is offered in the spring semesters. These two courses use the same teaching format to cover diseases of the cardiovascular, pulmonary, and renal systems (PHOL 479) and by Clinical Reasoning II (PHOL 492), which is offered in the spring semesters. These two courses use the same teaching format to cover diseases of the cardiovascular, pulmonary, and renal systems (PHOL 479) and of the gastrointestinal, endocrine, and reproductive systems (PHOL 492). Each of the Clinical Reasoning Courses can be taken independent of the others. All three courses require the Course Director's approval and are open to graduate students in biomedical related masters programs across campus.
| Kui Xu, MD, PhD | 216-368-5950 | kui.xu@case.edu |
PHOL 497A (Fall) & PHOL 497B (Spring): Neurology Grand Rounds (1 credit hour each) (Pass/Fail)
This course (Neurology Grand Rounds) is a weekly seminar series offered fall and spring semesters by the Department of Neurology at University Hospitals Case Medical Center. The course can be taken online (1 credit, once weekly - 1 hr / session).
| Erika N Allen, PhD | 216-368-3400 | erika.allen@case.edu |
| George R. Dubyak, PhD | 216-368-5523 | george.dubyak@case.edu |
Weekly one-hour reviews by faculty or invited speakers on their research. PhD students should enroll in PHOL 498A and 498B. Masters students should enroll in PHOL 498C and PHOL 498D.
| George R. Dubyak, PhD | 216-368-5523 | george.dubyak@case.edu |
One-semester experience in a selected faculty research laboratory designed to introduce the student to all aspects of modern laboratory research including the design, execution, and analysis of original experimental work.
| Julian E. Stelzer, PhD | 216-368-8636 | julian.stelzer@case.edu |
The goal of this course is to provide the student with a solid foundation in cardiovascular physiology and pathophysiology. The course will span topics in basic cellular and molecular function to in vivo cardiac physiology and pathophysiology. The course requires a solid foundation in cardiovascular physiology and experience in review and interpretation of scientific literature. Students are expected to participate in class discussions and present on various topics covered in class.
This intense lecture and laboratory-based course will cover basic concepts of light microscopy and introduce advanced techniques relevant to modern cell and molecular biology. Students will gain extensive hands-on experience with state-of-the-art equipment for optical imaging guided by experienced academic instructors. The latest and most advanced instrumentation for light microscopy, image detection, and computerized image analysis will be available for us in the laboratory part of this course.
| Peter MacFarlane, PhD | 216-368-4628 | peter.macfarlane@case.edu |
This course is designed to integrate systemic, cellular and molecular aspects of cardio-respiratory systems in physiological and pathophysiological states. The course requires prior knowledge of basic physiology of the cardiovascular systems. Extensive student participation is required. Instructors provide a brief overview of the topic followed by presentation and critical appraisal of recent scientific literature by students.
| Xin Qi, PhD | +12163684459 | xin.qi2@case.edu |
Cellular physiology laboratory research activities that are based on faculty and student interests. (1-36 credtis)
| Kui Xu, MD, PhD | 216-368-5950 | kui.xu@case.edu |
The discussion course presents the significance and consequences of oxygen and oxygen metabolism in living organisms. Topics to be covered include oxygen transport by blood tissues, oxygen toxicity, and mitochondrial metabolism. Emphasis will be placed on mammalian physiology with special reference to brain oxidative metabolism and blood flow as well as whole body energy expenditure and oxidative stress related to disease. (1 credit- once weekly - 1 hr/session) Permission of instructor required. This discussion course is open only to students who are currently enrolled in PHOL 410 or who have previously taken PHOL 410.
| Lisa Damato, PhD | 216-368-5634 | egd@case.edu |
| Michael J. Decker, PhD | 216-368-2467 | mjd6@case.edu |
Participants in this course will gain an understanding of the neural mechanisms contributing to the states of sleep and wakefulness. Contemporary theories regarding why humans need to sleep will be reviewed. We will also review how perturbations within specific neurotransmitter systems become manifest as sleep related disorders and the pharmacological interventions used to normalize activity within those neural pathways.
| Kui Xu, MD, PhD | 216-368-5950 | kui.xu@case.edu |
Each course is a 2 week intensive experience offered summer, fall, and spring semesters on a schedule set by the Department of Neurology at University Hospitals Case Medical Center. Students are expected to be present and observe at all of the times set forth by the house staff and attending, generally a 40 hour week minimum. The objective of the course is to provide the students with the experience of observing patient care provided by 3rd year medical students on a clinical rotation under direct supervision by house staff and attending on an active acute Neurology Service. They will learn the basics of neurological history-taking, neurological examination, neurodiagnostic studies, and neurological therapeutic. Unlike the medical students on the rotation, a Clinical Observer will only observe procedures and will not actively take part in any health care – he/she will act strictly as an observer, but will act as a physiological consultant to the team responsible for providing basic science input to the clinical cases.
| Andrea Romani, MD, PhD | 216-368-1625 | andrea.romani@case.edu |
(credit as arranged)
| Xin Qi, PhD | +12163684459 | xin.qi2@case.edu |
(credit as arranged)
