Physiology & Biophysics

Mouse Physiological Phenotyping Core (MPPC)


Welcome to the Mouse Physiology Phenotyping Core (MPPC)

The MPPC in the Department of Physiology and Biophysics (DPB) is a state-of-art laboratory with instrumentation allowing investigators to characterize various aspects of small animal physiology. Assessment of clinical parameters in blood samples is possible with analyzers for blood gases (Prime, Nova), customizable clinical chemistries (Dri-Chem, Heska) and hematology (HemaTrue, Heska). The MPPC also houses instrumentation to assay rodent exercise tolerance with exercise wheels (mouse, Lafayette Instruments, Inc.). In addition, the MPPC have access to a treadmill system (mouse/rat, Columbus Instruments) which includes a 3/6 lane practice treadmill and single treadmills enclosed for calorimetry. Both systems have adjustable incline. We also run a 4 chamber mouse Metabolic Cages system with feeding/drinking event and amount monitoring as well as waste collection that will freeze metabolic samples (Columbus Instruments).  Additional systems are available for telemetry studies, blood pressure monitoring & plethysmography. The MPPC possesses a Biospherix Oxycycler with 4 glovebox accessible chambers which to allow investigators to condition (mice/rats) or insert exercise mice (wheels) in 4 separate, customizable O2 & CO2 environments. The MPPC operates as a multi-investigator, shared-used facility and provides training, technical expertise and assistance to all users. All instrumentation may be used with a small fee to cover consumables.

If you would like to learn more or schedule a service, please email Jessica Berthiaume at jessica.berthiaume@case.edu or Gerald Babcock at gerald.babcock@case.edu or call 216-36-4766 for available time and services.

Location

Case Western Reserve University, School of Medicine
Laboratory Space: Biomedical Research Building, B55 and B53
Main Office: Robbins Building, E549