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Journal Club

Sara Taki
Sara Taki
Nov. 20, 2019 8:45 a.m. - 9:45 a.m.
School of Medicine E501
Mentor: Walter F. Boron, MD, PhD

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"Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization "

Cell 175, 117–132, September 20, 2018 © 2018 Elsevier Inc.

William J. Sullivan, Peter J. Mullen,1 Ernst W. Schmid, Aimee Flores, Milica Momcilovic, Mark S. Sharpley, David Jelinek, Andrew E. Whiteley, Matthew B. Maxwell, Blake R. Wilde, Utpal Banerjee, Hilary A. Coller, David B. Shackelford, Daniel Braas, Donald E. Ayer, Thomas Q. de Aguiar Vallim, William E. Lowry, and Heather R. Christofk

The metabolic state of a cell is influenced by cellextrinsic factors, including nutrient availability and growth factor signaling. Here, we present extracellular matrix (ECM) remodeling as another fundamental node of cell-extrinsic metabolic regulation. Unbiased analysis of glycolytic drivers identified the hyaluronan-mediated motility receptor as being among the most highly correlated with glycolysis in cancer. Confirming a mechanistic link between the ECM component hyaluronan and metabolism, treatment of cells and xenografts with hyaluronidase triggers a robust increase in glycolysis. This is largely achieved through rapid receptor tyrosine kinasemediated induction of the mRNA decay factor ZFP36, which targets TXNIP transcripts for degradation. Because TXNIP promotes internalization of the glucose transporter GLUT1, its acute decline enriches GLUT1 at the plasmamembrane. Functionally, induction of glycolysis by hyaluronidase is required for concomitant acceleration of cell migration. This interconnection between ECM remodeling and metabolism is exhibited in dynamic tissue states,including tumorigenesis and embryogenesis.