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Yi-Wei Chang, PhD
Assistant Professor of Biochemistry and Biophysics
Perelman School of Medicine, University of Pennsylvania
PhD, Structural Biology, Academia Sinica & National Tsing Hua University (Taiwan)
Cert, Research Mentor Training: Effective Communication And Aligning Expectations, Perlman SOM, University of Pennsylvania
BS, Mechanical Engineering, Chung Hua University (Taiwan)

Mailing Address:
Philadelphia , PA

Research Interests

Structure of macromolecules determines function. The Chang lab in the University of Pennsylvania is deeply interested in understanding the basis of biology from a structural perspective. Distinct from many other structural biology groups working with purified macromolecules, the Chang lab utilizes cryo-electron tomography (cryo-ET), a powerful cryo-electron microscopy imaging technique, to study the structure and mechanism of macromolecular machines directly inside cells. In the cellular context, cryo-ET reveals not only native conformations and assemblies of the macromolecular machines as they are conducting functions, but also their distribution, orientation and interaction with other cellular components – thus providing a unique opportunity to uncover structural mechanisms of complex cellular activities such as host-pathogen interactions. 


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