The Vallon lab aims to integrate aspects of vascular, tubular and metabolic function to gain a more complete understanding of renal physiology, pathophysiology and pharmacology. The group has characterized the roles played by a variety of ion channels, transporters, receptors and intracellular signaling pathways in the biology of the kidney. The work offers new insights into the role of the kidney in the regulation of blood pressure, the excretion and renal clearance of exogenous and endogenous compounds, and the underlining pathophysiology of the early diabetic kidney as well as of acute kidney injury (AKI) and chronic kidney disease (CKD). The work is a blend of physiology, molecular biology and pharmacology. It uses gene-targeted mouse models to dissect contributions of specific genes and address clinically relevant questions. The group is one of few that performs in vivo renal micropuncture at the single nephron level of rodents.

Source: https://medschool.ucsd.edu/som/medicine/divisions/nephrology/research/Basic%20and%20Translational%20Research/Pages     /Volker-Vallon.aspx