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Shrawan Kumar Mageswaran, PhD
Postdoctoral Researcher / Cryo-ET Techincal Director / Lab of Yi-Wei Chang, Ph.D.
Perelman School of Medicine, University of Pennsylvania

Mailing Address:
Philadelphia , PA

Research Interests

Structure of macromolecules determines function. The Chang lab in the University of Pennsylvania is deeply interested in understanding the basics of biology from a structural perspective. Distinct from most of the other structural biology groups working with purified macromolecules, the Chang lab utilizes cryo-electron tomography (cryo-ET), a powerful cryo-electron microscopy imaging technique, to study the structure and mechanism of macromolecular machines directly inside cells. In the cellular context, cryo-ET reveals not only native conformations and assemblies of the macromolecular machines as they are conducting functions, but also their distribution, orientation and interaction with other cellular components – thus providing a unique opportunity to uncover structural mechanisms of complex cellular activities such as host-pathogen interactions.  


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