Current Research Projects

Project 1.-  Role of amyloid beta, synaptic pathology and mitochondrial dysfunction in Alzheimer's disease pathogenesis. Currently, my lab is investigating the roles of amyloid beta, synaptic pathology and mitochondrial oxidative damage in the development and progression of Alzheimer's disease (AD).

Project 2. -  Mitochondrial therapeutics in Alzheimer's disease. My lab is also investigating to determine whether mitochondrially targeted antioxidants (MTAs) reduce oxidative damage and amyloid beta pathology, increase neurite outgrowth and ameliorate cognitive deficits in APP transgenic mice.

Project 3. -  Mitochondrial dynamics in alcohol, aging and gender In another project, we are studying the mitochondrial DNA changes and mitochondrial dynamics (fission and fusion balance) in the brains of male and female, and young and aged nonhuman primates, nonhuman primates fed with ethanol, laboratory mice and humans, in order to determine the effect of age, gender and alcohol, in mitochondrial structure and function, and cell survival.

Project 4. - Using postmortem brains from patients with Huntington's disease (HD) and transgenic mice from HD, the Reddy lab is exploring the role of abnormal mitochondrial dynamics in the progression of HD.  Further, Reddy lab is also investigating the mechanisms of transport of mutant huntingtin oligomers into nucleus and other subcellular organelles in neurons affected by HD.

Project 5. - Using primary neurons from transgenic mouse models of Aging, AD and HD and live-cell imaging tools, Reddy and colleagues are extensively investigating axonal transport of mitochondria, mitochondrial biogenesis and synaptic activity.

Source:  http://www.ohsu.edu/xd/education/schools/school-of-medicine/academic-programs/graduate-studies/faculty/grad-studies-faculty.cfm?facultyid=294