Dr. Chesler received his MD and PhD from the NYU MSTP, finishing in 1986. After post-doctoral work he returned to NYU SOM and joined the Dept. of Neurosurgery and the Dept. of Physiology and Neuroscience. Dr. Chesler's laboratory is interested in the role of hydrogen ions as signals in normal and pathological brain function. Studies emphasize the neural and glial mechanisms that transport H+ or bicarbonate, and thereby give rise to shifts in intracellular and extracellular pH, in time frames from milliseconds to minutes. Experiments focus on the regulation of these putative signals, and their role in shaping neuronal excitability, synaptic transmission, and metabolic responses. These subjects are addressed under normal conditions, and in pathological settings such as seizure, migraine, ischemia, and glioma.