The Shoulders Lab is developing and applying a chemical biology and small molecule-derived toolbox to probe the cell's protein folding network and manipulate it in defined ways. We employ a multi-disciplinary approach to understand how the cell remodels itself to address challenges to protein homeostasis, to elucidate the pathophysiology of protein folding-related diseases with poorly defined etiologies, and to target the biological processes we uncover for the development of first-in-class small molecule drugs.

Source:  https://shoulderslab.mit.edu/research-interests