CWRU Links
Manfred Lindau
Case Western Reserve University

Mailing Address:
Ithaca , NY NA
Phone: 216-368-3400
Fax: 216-368-5586

Research Interests

How SNAREs open the fusion pore

•    Characterization of the biological membrane fusion mechanism in chromaffin cells by biophysical measurements using mutated constructs of the proteins synaptobrevin and SNAP-25
•    Investigation of single fusion pore openings pore in chromaffin cells using capacitance measurements and amperometry
•    Investigation of the dynamics of exocytosis in whole cell patch clamp capacitance measurements stimulated by flash photolysis of caged calcium
•    Development of microfabricated transparent amperometric detector devices to relate fluorescence imaging of molecular events with electrochemical detection of vesicle fusion
•    Development of high-throughput microchip devices for electrochemical screening of drugs affecting transmitter release
•    Characterization of docking and fusion between secretory granules and between specific components of the exocytotic machinery using optical tweezers and atomic force microscopy