Membrane Protein Structure
A third of all proteins and the vast majority of drug targets are membrane proteins. In spite of their biological and medical importance, our understanding of membrane protein structure and function is still at a rudimentary level and our tools for working with membrane proteins are primitive. The questions we are addressing in this area are:
SAM Domains: A Biological Polymer
SAM domains are one of the most common protein modules found in eukaryotic cells. We discovered that many SAM domains can form polymers, establishing the existence of a new biological polymer that can be used to build complex biological structures. The questions we address in this area are:
Developing new sources of energy is a grand challenge for science in the coming decades. We are working to utilize micro-organisms to convert carbon dioxide and light into biodiesel.