Specialty: Cardiovascular physiology Major Interest: Neural control of the circulation; angiotensin II; nitric oxide; reactive oxidant stress
Specialty: Cardiovascular physiology
Major Interest: Neural control of the circulation; angiotensin II; nitric oxide; reactive oxidant stress
Research in the Zucker laboratory focuses on the role of the central brain mechanisms on neurohormonal adjustments in cardiovascular regulation in the setting of experimental chronic heart failure. The lab is interested in the role of substances such as angiotensin II, ACE2, nitric oxide and reactive oxidant stress as important mediators of sympathetic excitation in the setting of chronic heart failure. Molecular, cellular and whole animal techniques are used to understand abnormal cardiovascular and neural regulation in heart failure. In addition, the Zucker lab is extremely interested in the role of exercise training in ameliorating some of the abnormalities it has found in the central nervous system of animals with heart failure.
A secondary interest relates to the role of cardiac sympathetic sensory endings in mediating sympatho-excitation and cardiac remodeling in heart failure and hypertension.
These techniques are providing important new information about normal cardiovascular physiology and about the pathophysiology of heart failure and other cardiovascular diseases.
Students in the Zucker laboratory learn surgical preparation of chronically instrumented animals and techniques for measuring a variety of cardiovascular parameters in awake, chronically instrumented animals. Molecular biological techniques such as Western blots, real time RT PCR and histological techniques are routinely used.