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Holger Sondermann, PhD
Associate Professor
Cornell University College of Veterinary Medicine

Mailing Address:
C4 175 Veterinary Medical Center
Ithaca , NY 44116-4970
Phone: 607-253-3318
Fax: 607-253-3659

Research Interests

My lab is interested in deciphering the basic regulatory principles in signal transduction networks on a molecular level, focusing on growth factor receptor signaling. In particular, we study the role of scaffolding proteins and other regulators signal transduction in this pathway, using a combination of X-ray crystallography, biophysical and cellular approaches. Scaffolds, which serve as docking hubs for the signaling switches, provide specificity and higher-order control in signaling reactions. Understanding the architecture, mode of action and regulation of these processes will elucidate how cells respond to various inputs producing distinct outputs by using a limited set of molecules.

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