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David W. Piston, PhD
Edward Mallinckrodt, Jr. Professor and Head, Department of Cell Biology and Physiology
Washington University School of Medicine in St. Louis
PhD, Physics, University of Illinois (Urbana)
MS, Physics, University of Illinois (Urbana)
BA, Physics, Grinnell College

Mailing Address:
St. Louis , MO

Research Interests

The main research focus of the Piston lab is the understanding of glucose-regulated hormone secretion from islets of Langerhans in the pancreas. To perform live cell measurements in situ and in vivo, his lab develops unique, state-of-the-art fluorescence imaging methods to assay responses along critical signaling pathways in both glucagon-secreting α-cells and insulin-secreting β-cells. These quantitative microscopy measurements are combined with standard biochemical and molecular biological techniques to obtain valuable information that bridges the gap between the known details of the signaling pathways in individual cells and the overall response of a whole islet. Experimental work involves 5D live cell imaging and high-content screening.





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