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David M. Jameson, PhD
University of Hawai'i at Manoa

Mailing Address:
Honolulu , HI
Phone: 808-956-8332

Research Interests

The Jameson laboratory utilizes fluorescence methodologies to elucidate dynamic aspects of biomolecules.  The lab is currently studying dynamin, a large (98kDa) GTPase which functions to “pinch-off” membrane vesicles in pathways such as receptor mediated endocytosis and synaptic vesicle recycling.  The Jameson lab carries out both in vitro and in vivo studies on the self-association modes of dynamin as well as its interaction with membranes and other proteins such as endophilin Arc/Arg3.1.  The lab also has a project on Botulinum Neurotoxin which involves biophysical studies on proteins forming the neurotoxin complex as well as development of in vitro and in vivo toxin assays based on Fluorescence Fluctuation Spectroscopy.


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