The overarching goal of the Wenceslau laboratory is to understand vascular physiology in cardiovascular diseases. The lab studies the mechanisms associated with the vascular-immune network in hypertension, metabolic syndrome and sepsis. Specifically, it questions why immunoreceptors that are crucial for chemotaxis and inflammation in sentinel cells are expressed in the vasculature. Further, does activation or inhibition of these receptors play a role in the vascular physiology and pathophysiology? To answer these questions, the Wenceslau laboratory employs a wide range of cutting-edge techniques and multidisciplinary in vivo and in vitro experimental approaches including clinically relevant diseased mouse and rat models, radiotelemetry, vascular isobaric and isometric force measurement, and biochemical and molecular biology methods. The work of the lab has been previously supported by the American Heart Association (AHA) and it is currently funded by the NIH [NHLBI (R01) and NIGMS (R00)].