The Liang Laboratory focuses on integrating the power and advantages of different imaging system modalities, including those using electrons, x-rays, and visible lights, and scrutinizing how macromolecular machinery functions in various biological processes in real-time at unprecedented resolution. Capitalizing on breakthroughs in detector technology and image processing algorithms, the Liang laboratory is particularly interested in using cryo-electron microscopy (cryo-EM), the technology that won the 2017 Nobel Prize in Chemistry, as a primary tool to visualize macromolecular complexity. Cryo-EM is exceptionally well suited for molecular systems traditionally challenging for structural characterization, including membrane proteins and large and heterogeneous assemblies. Also, the lab employs x-ray crystallography and fluorescence light microscopy to provide complementary structural and dynamic information for challenging systems of significant biological importance.

Source: https://med.emory.edu/departments/biochemistry/research-labs/liang/research.html