The overarching goal of the Stahl laboratory is to advance human health by re-engineer lipid fluxes in the context of obesity-related disorders to protect certain tissues, such as the liver, from detrimental effects of ectopic lipid deposition and to generate metabolically highly active tissues that can serve as a save destination for excess fatty acids. To this end, the lab is investigating molecular mechanisms governing lipid uptake, particularly for fatty acids and CoQ, hepatobiliary diseases, and adipocyte biology. Toward the latter, it has been working on novel bioengineering based approaches to expand and activate brown adipose tissue. Further, to facilitate the assessment of altered nutrient fluxes, the lab has been developing and testing novel bioluminescent imaging approaches to quantitatively assess macro- and micronutrients in vivo and has been working as part of a multidisciplinary team toward modeling human metabolic function and disease using iPSC based microphysiological systems, aka organs-on-a-chip, for adipocytes, hepatocytes, and islets.

https://vcresearch.berkeley.edu/faculty/andreas-stahl