The Xiao lab uses structural and chemical biology approaches to study the inflammasome signaling pathways, with the goal of targeting diverse diseases such as sepsis, multiple sclerosis, and AIDS using small molecule compounds.

Two areas of active research are molecular mechanism of pyroptosis mediated by the gasdermin family of pore-forming proteins and regulation of inflammatory caspases using chemical biology approaches for drug development.

Source:  https://case.edu/medicine/pathology/faculty/tsan-sam-xiao