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M. Michael Wolfe
M. Michael Wolfe
Case Western Reserve University
Dec. 20, 2010 4 p.m.
School of Medicine E501
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"Obesity, Incretins, and the GI Tract: You Are What You Eat"


M. Michael Wolfe, M.D. is Chair of the Case Western Reserve University Department of Medicine at MetroHealth Medical Center, Cleveland, OH, where he is the Charles H. Rammelcamp, Jr. Professor of Medicine at Case Western Reserve University.  From 1996 to 2010, he served as Chief of the Section of Gastroenterology at Boston Medical Center and Boston University School of Medicine, and also was Professor of Medicine and Research Professor of Physiology and Biophysics.  A native of Akron, Ohio (USA), Dr. Wolfe received his undergraduate and medical education at The Ohio State University in Columbus, Ohio.  Following his graduation from medical school, he completed a residency in internal medicine at the Medical College of Pennsylvania in Philadelphia, Pennsylvania, where he served as Chief Medical Resident. In 1979, Dr. Wolfe began his research and clinical fellowships in gastroenterology at the University of Florida, where he gained considerable expertise in the regulation of gastric acid secretion and peptic ulcer disease, as well as in the field of gastrointestinal regulatory peptides.  In November 1985, Dr. Wolfe relocated to Harvard Medical School, where he continued his investigative career and became one of the pioneers in studies that examined the transcriptional regulation of gastrin and other peptides.  In November 2010, he assumed his current positions at Case Western Reserve University and MetroHealth Medical Center.  His current research interests include the physiological and pathological significance of glucose-dependent insulinotropic polypeptide and specifically its role in the pathogenesis of obesity.  He is also conducting research aimed at the use of stem cells programmed to express therapeutic peptides for the treatment of various hereditary and acquired deficiency states.  His clinical investigation includes the management of acid-related disorders and novel methods for the treatment and prevention of obesity.




Dr. Wolfe has also achieved significant recognition for his continued interest in acid-related disorders and specifically GERD and NSAID-associated gastroduodenal ulcers and in the diagnosis and management of gastrinoma and other neuroendocrine tumors.  He has been named to several local and national “Best Doctor” lists over the past several years, including “Best of Boston” in 2008 and 2009, and he is a Fellow of the American Gastroenterological Association (AGA), the American College of Physicians, and the American College of Gastroenterology.  Dr. Wolfe served as Co-Chair of the annual AGA Gastroenterology Division Chief Workshop in November 2006, and he was formerly Chair of the AGA Constitution and Bylaws Committee, a member of the AGA Research Committee, a member of the AGA Training and Education Committee, and Chair of the GERD Awareness Program (GAP) of the AGA.  In addition to his numerous and significant contributions to the gastroenterological literature, he is on the editorial boards of Digestive Diseases and Sciences and Regulatory Peptides, and served as a member of the editorial board of The American Journal of Physiology.  Dr. Wolfe has edited several clinical medicine textbooks, including his role as Editor-in-Chief of both editions of Therapy of Digestive Disorders, and was co-author of Heartburn: Extinguishing the Fire Inside.  In all, he has authored or co-authored over 300 original scientific manuscripts, chapters, reviews, and abstracts.  He was a member of the ZRG F10 Study Section of the National Institutes of Health for several years and served as Chair of the Advisory Board for Gastrointestinal Drugs at the U.S. Food and Drug Administration from July 1, 2001 to June 30, 2003.