CWRU Links

Current research/resources

The current (2018) efforts are directed to analyzing and interpreting transcriptomics data.

Previosu work had established kidney cell lines, in particular proximal tubule cell lines from a normotensice and a hypertensive rat strain, from wild type, AT1a KO, AT2 KO, AT1b KO, and AT1a/b double KO mouse strains, and from 3 human donors, as well as a wild-type corical collecting duct cell line from mouse (see publications below). These cell lines are maintained by Dr. Michael Romero, Professor of Physiology,  Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester MN, e-mail:

Hopfer Kidney Cell Lines are maintained at CWRU by Dr. Xin Qi, The database and related information is at Kidney Cell Lines

1: Woost PG, Kolb RJ, Chang CH, Finesilver M, Inagami T, Hopfer U. Development of
an AT2-deficient proximal tubule cell line for transport studies. In Vitro Cell
Dev Biol Anim. 2007 Nov-Dec;43(10):352-60. Epub 2007 Oct 26. PubMed PMID:
2: Woost PG, Kolb RJ, Finesilver M, Mackraj I, Imboden H, Coffman TM, Hopfer U.
Strategy for the development of a matched set of transport-competent, angiotensin
receptor-deficient proximal tubule cell lines. In Vitro Cell Dev Biol Anim. 2006 
Jul-Aug;42(7):189-200. PubMed PMID: 16948500.
3: Orosz DE, Woost PG, Kolb RJ, Finesilver MB, Jin W, Frisa PS, Choo CK, Yau CF, 
Chan KW, Resnick MI, Douglas JG, Edwards JC, Jacobberger JW, Hopfer U. Growth,
immortalization, and differentiation potential of normal adult human proximal
tubule cells. In Vitro Cell Dev Biol Anim. 2004 Jan-Feb;40(1-2):22-34. PubMed
PMID: 14748622.
4: Woost PG, Orosz DE, Jin W, Frisa PS, Jacobberger JW, Douglas JG, Hopfer U.
Immortalization and characterization of proximal tubule cells derived from
kidneys of spontaneously hypertensive and normotensive rats. Kidney Int. 1996
Jul;50(1):125-34. PubMed PMID: 8807581.