Physiology & Biophysics

Garvin Lab


Research Topics

The work in my laboratory focuses broadly on the regulatory mechanisms that maintain salt and water homeostasis. We have worked on a wide range of problems from transport of salt by fish gills to models of salt-sensitive hypertension. We address these problems using state of the art, cutting edge research tools. Many of these tools were developed by students and postdocs in the lab. Currently we are working on several projects concerning why defects that reduce the biological actions of  NO and/or increase the actions of angiotensin II and O2- in the kidney lead to hypertension. This is a critical problem as about 25% of the U.S. population is afflicted with this disease, and the prevalence increases with age such that by 65 nearly 60% of us will have hypertension. Furthermore, hypertension is the leading cause of “loss of health” world-wide.

Training Philosophy

Training the next generation of scientists is the duty of all investigators, especially those that have been successful. Our most important responsibility is to show young investigators the joy of discovery. While this must come with rigorous scientific training and preparation for the trials new independent scientists face when setting up their labs, few other experiences are as rewarding. Students and postdocs in my lab are given significant, career-appropriate responsibilities for their projects and are held to very high standards. My lab size is limited so that each individual receives my direct attention.  

Principal Investigator: Jeffrey L. Garvin, PhD
Contact Email: jeffrey.garvin@case.edu
Contact Phone: 216-368-3353

Projects:

Dietary salt alters the balance of flow-induced NO and O2- in thick ascending limbs causing salt-sensitive hypertension

Regulation of thick ascending limb transport by angiotensin II

Dietary fructose enhances the sensitivity of proximal tubules to angiotensin and causes salt-sensitive hypertension