Physiology & Biophysics

Mu Lab


Understanding ion channel protein homeostasis in the cell

My laboratory aims to understand ion channel protein homeostasis in the cell. We focus on studying gamma-aminobutyric acid type A (GABAA) receptors and potassium channels, KCNH2. Mutations in ion channels can lead to protein misfolding and extensive ER-associated degradation (ERAD), causing ion channel diseases, such as idiopathic epilepsy and cardiac arrhythmias, due to a lowered concentration of ion channels in cell membranes and thus loss of function. We explore how molecular chaperones and folding enzymes coordinate to facilitate ion channel folding and trafficking. We also use small molecules to correct misfolded ion channels, as a therapeutic strategy to treat epilepsy.

Principal Investigator: Tingwei Mu, PhD
Contact Email: tingwei.mu@case.edu
Contact Phone: 216-368-0750

Projects:

1. Understanding the Molecular Mechanism of Ion Channel Folding in the Cell.
2. Ameliorating Ion Channel Misfolding Diseases.