CWRU Links

PEPCMBC Publications

The PEPCC staff will provide technical assistance to the extent required. Users are requested to acknowledge the PEPCC at department of Physiology and biophysics in resulting publications and presentations and email Dr. Yinghua Chen at about these publications or presentations.

Here are some examples of acknowlegment:

Assistance with XXX measurement from PEPCC at department of Physiology and Biophysics, Case Western Reserve University is appreciated.

If staff design the experiment for you or provide intellectual contribution to a project, please recognize them as an author on the paper.


Below are selected publications that used the equipment in our facility:


Xu M, Axhemi A, Malgowska M, Chen Y, Leonard D, Srinivasan S, Jankowsky E, Taylor DJ. Active and Passive Destabilization of G-Quadruplex DNA by the Telomere POT1-TPP1 Complex (2021). J. Mol. Biol. 433(7):166846


Lin K, Zhang L, Kong, M, Yang MJ, Chen Y, Poptic E, Hoffner M, Xu J, Tam C, Lin F. Development of an anti-human complement C6 monoclonal antibody that inhibits the assembly of membrane attack complexes (2020). Blood Adv. 4 (9): 2049–2057.

Liu Z, Wang C, Yang J, Chen Y, Zhou B. Abbott DW, Xiao TS. Caspase-1 Engages Full-Length Gasdermin D through Two distinct interfaces That Mediate Caspase Recruitment and Substrate Cleavage (2020), Immunity 53(1):6-8

Leonard D , Huang W, Izadmehr S, O’Connor CM , Wiredja D, Wang Z, Zaware N, Chen Y, Schlatzer D, Kiselar J , Vasireddi N, Schüchner N, Perl AL , Galsky M, Xu W , Brautigan DL , Ogris E, Taylor DJ, Narla G. (2020) Selective phosphatase enhancement through biased heterotrimer stabilization. Cell. 181(3):688-701



Montano MM, Yeh I, Chen Y, Hernandez C, Kiselar JG, Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, and Lawes MC (2019) Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cell (2019), Breast Cancer Res. 21(1):138

Peng Y, Cao S, Kiselar J, Xiao X, Hsien A, Chen Y, Shi W, Jiang W, Yang L, Chance MR, Surewicz W, Buck M, and Yang S (2019) Metastable contacts and structural disorder in the estrogen receptor transactivation domain. Sturcture, 27(2):229-240


Vaynberg J, Fukuda K, Lu F, Bialkowska K, Chen Y, Plow EF, and Qin J (2018) Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion, Nat Commun. 9(1):4465

Huang W, Peng Y, Kiselar J, Zhao X, Albaqami A, Mendez D, Chen Y, Chakravarthy S, Gupta S, Ralston C, Kao H, Chance M, and Yang S (2018) Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains. Nat commun. 9(1):3520

Rathkey JK , Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC , Benson BL, Chirieleison SM, Huang AY, Dubyak GR , Xiao TS,  Li XX , Abbott DW (2018) Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis  Sci immuol.

Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, and Xiao TS (2018) Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor PNAS

Perez J, Chen Y, Xiao T and Abbott DW (2018) Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase JBC. 293(3) 1100 –1105


Lee PW, Shukla S, Wallat, JD, Danda C, Steinmetz NF, Maia JM, Pokorski JK (2017) Biodegradable Viral Nanoparticle/Polymer Implants Prepared via Melt-Processing. ACS Nano. In Press 

Lee PW, Maia J, Pokorski JK (2017) Milling Solid Proteins to Enhance Activity after Melt-Encapsulation. Int. J. Pharm. In Press


Tai W, Zhao G, Sun S, Guo Y, Wang Y, Tao X, Tseng CK, Li F, Jiang S, Du L, Zhou Y (2016) A recombinant receptor-binding domain of MERS-CoV in trimeric form protects human dipeptidyl peptidase 4 (hDPP4) transgenic mice from MERS-CoV infection. Virology, 499, 375-382

Gao Z, Putnam A, Bowers H, Guenther U, Ye X, Kindsfather A, Hilliker A andJankowsky E (2016) Coupling between the DEAD-box RNA helicases Ded1p and eIF4A. eLife 5:e16408


Zhang J, Kiser P, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop G and Palczewski K (2015) Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin. Invest. 125, 2781-2794.

Han Z, Zhou Z, Shi X, Wang J, Wu X, Sun D, Chen, Y, Zhu H, Magi-Galluzzi, C, Lu, Z (2015) An EDB fibronectin specific peptide for prostate cancer targeting. Bioconjug Chem. 26(5): 830-838.

Cao P, Su Z, Leon A, and Advincula R (2015) Photoswithable nanocarrier with reversible encapsulation properties. MacroLetters 4, 58-62.


Mehrotra N, Nichols J, and Ramachandran R (2014). Alternate pleckstrin homology domain orientations regulate dynamin-catalyzed membrane fission. Mol Biol Cell 25, 879-890.

Macdonalda PJ, Stepanyantsa N, Mehrotraa N, Mears JA, Qi X, Sesakid H, and Ramachandrana R (2014). A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission. Mol Biol Cell 25, 1905-1915.


Ruschak AM, Rose JD, Coughlin MP, Religa TL (2013) Engineered solubility tag for solution NMR of proteins. Protein Sci 22, 1646-1654