CWRU Links
Xin Qi, PhD
Associate Professor
PhD, Hokkaido University, Japan
Postdoctoral Training, Stanford University

Mailing Address:
Robbins E516
Phone: 216-368-4459
Fax: 216-368-5586

Research Interests

Mitochondrial quality control and neurodegenerative diseases

Our laboratory focuses on understanding the roles of mitochondrial quality control in neurodegenerative diseases. We use the combination of unbiased proteomics and genomics, cellular and molecular biology, genetic manipulation in vitro and in vivo, patient iPS cells-derived cell culture and diseased animals to investigate the fundamental mechanisms and pathways by which mitochondrial impairment contributes to neurodegeneration. We also utilize rationally designed peptide inhibitors of protein-protein interactions and high throughput screening approach to developing “mitochondrial medicine” as therapeutic strategies for treating neurodegenerative diseases. 

Mitochondria are critical organelles for cellular function through regulation of energy metabolism, ATP generation, and calcium handling. Dysfunctional mitochondria elicit the production of ROS and the deficits in energy supply, which ultimately affect numerous biological processes, including cellular bioenergetics, immune response, genomic stability and programmed cell death. 

To attenuate these negative effects, mitochondria deploy several quality control pathways that are essential to maintain their pleiotropic functions and reduce mitochondrial stress.  Mitochondrial quality control includes mitochondrial dynamics (fusion/fission), mitochondrial unfolded protein response (UPRmt) and mitochondria-related autophagy (mitophagy). These events are to repair damaged mitochondrial proteins, to facilitate mitochondrial adaption to the stress and to remove/degrade the irreversibly damaged mitochondria.  

One of our research focuses is to understand the roles of mitochondrial dynamics-related proteins in mitochondrial and cellular functions, especially in the context of neurodegenerative diseases. Using a set of inhibitors targeting aberrant mitochondrial fission, we are determining whether manipulation of mitochondrial dynamics could provide a useful strategy for the treatment of neurodegenerative diseases. As another arc of research, we utilize unbiased proteomics to identify factors that participate in the regulation of UPRmt and mitophagy. We aim to understand how protein homeostasis of mitochondria controls cell life and influences neurodegeneration. 

Featured Publications
Related Research Areas