Heart damage in mammals is generally considered to result in formation of a scar, whereas some lower vertebrates can completely regenerate their hearts following an intermediate and reversible state of fibrosis. The Senyo group is interested in understanding fundamental mechanisms regulating the differential regenerative response observed across species, across ages, and in distinct forms of injury. Toward this aim, Dr. Senyo performs comparative studies using mammalian model systems, including human stem cells. For example, Dr. Senyo and colleagues have investigated the role of native progenitor cells in endogenous formation of new musculature in the adult mammalian heart using isotope tracers, transgenics, and novel imaging tools. Through collaboration and in-house method development, the Senyo group seeks to take lessons from similar studies to develop new treatments for human disease and to foster a community of new scientists in academia and the private sector.