Physiology & Biophysics

Isabelle Deschenes, PhD
Professor
PhD, Experimental Medicine, Laval University, Quebec, Canada

Metro Health Medical Center
Cleveland , OH 44106-4970
Phone: 216-778-5166
Fax: 216-778-1261
isabelle.deschenes@case.edu

Research Interests

Potentially lethal arrhythmias in rare inherited syndromes (idiopathic ventricular fibrillation) and more common, acquired heart diseases (cardiac hypertrophy and failure) have been associated with an imbalance of depolarizing (Na current) and repolarizing (Ito) current early in the ventricular action potential and a down regulation of Ito respectively. Our previous work demonstrated that cardiac Ito and INa form a macromolecular complex. Delineation of the molecular basis of this macromolecular complex formed by Ito and INa is essential for an accurate understanding of cardiac ventricular depolarization and repolarization and its derangements that are associated with lethal ventricular arrhythmias.