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PEPCMBC Publications

The PEPCC staff will provide technical assistance to the extent required. Users are requested to acknowledge the PEPCC at department of Physiology and biophysics in resulting publications and presentations and email Dr. Yinghua Chen at yinghua.chen@case.edu about these publications or presentations.

Here are some examples of acknowlegment:

Assistance with XXX measurement from PEPCC at department of Physiology and Biophysics, Case Western Reserve University is appreciated.

If staff design the experiment for you or provide intellectual contribution to a project, please recognize them as an author on the paper.

 

Below are selected publications that used the equipment in our facility:

  1. Molecular characterization of linker and loop-mediated structural modulation and hinge motion in the C4-C5 domains of cMyBPC. Doh CY, Bharambe N, Holmes JB, Dominic KL, Swanberg CE, Mamidi R, Chen Y, Bandyopadhyay S, Ramachandran R, Stelzer JE.J Struct Biol. 2022 Jun;214(2):107856.
  2. RANBP2 and USP9x regulate nuclear import of adenovirus minor coat protein IIIa. Ismail AM, Saha A, Lee JS, Painter DF, Chen Y, Singh G, Condezo GN, Chodosh J, San Martín C, Rajaiya J. PLoS Pathog. 2022 Jun 16;18(6):e1010588
  3. Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor. Mishra I, Xie WR, Bournat JC, He Y, Wang C, Silva ES, Liu H, Ku Z, Chen Y, Erokwu BO, Jia P, Zhao Z, An Z, Flask CA, He Y, Xu Y, Chopra AR. Cell Metab. 2022 Apr 5;34(4):549-563.e8.
  4. HBD-2 binds SARS-CoV-2 RBD and blocks viral entry: Strategy to combat COVID-19. Zhang L, Ghosh SK, Basavarajappa SC, Chen Y, Shrestha P, Penfield J, Brewer A, Ramakrishnan P, Buck M, Weinberg A. iScience. 2022 Mar 18;25(3):103856.
  5. Trimeric receptor-binding domain of SARS-CoV-2 acts as a potent inhibitor of ACE2 receptor-mediated viral entry. Basavarajappa SC, Liu AR, Bruchez A, Li Z, Suzart VG, Liu Z, Chen Y, Xiao TS, Buck M, Ramakrishnan P. iScience. 2022 Aug 19;25(8):104716.
  6. Integrin mediates cell entry of the SARS-CoV-2 virus independent of cellular receptor ACE2. Liu J, Lu F, Chen Y, Plow E, Qin J. J Biol Chem. 2022 Mar;298(3):101710.
  7. Active and Passive Destabilization of G-Quadruplex DNA by the Telomere POT1-TPP1 Complex. Xu M, Axhemi A, Malgowska M, Chen Y, Leonard D, Srinivasan S, Jankowsky E, Taylor DJ. J Mol Biol. 2021 Apr 2;433(7):166846.
  8. Selective PP2A Enhancement through Biased Heterotrimer Stabilization. Leonard D, Huang W, Izadmehr S, O'Connor CM, Wiredja DD, Wang Z, Zaware N, Chen Y, Schlatzer DM, Kiselar J, Vasireddi N, Schüchner S, Perl AL, Galsky MD, Xu W, Brautigan DL, Ogris E, Taylor DJ, Narla G. Cell. 2020 Apr 30;181(3):688-701.e16.
  9. Development of an anti-human complement C6 monoclonal antibody that inhibits the assembly of membrane attack complexes. Lin K, Zhang L, Kong M, Yang M, Chen Y, Poptic E, Hoffner M, Xu J, Tam C, Lin F. Blood Adv. 2020 May 12;4(9):2049-2057.
  10. Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage. Liu Z, Wang C, Yang J, Chen Y, Zhou B, Abbott DW, Xiao TS. Immunity. 2020 Jul 14;53(1):106-114.e5.
  11. Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. Montano MM, Yeh IJ, Chen Y, Hernandez C, Kiselar JG, de la Fuente M, Lawes AM, Nieman MT, Kiser PD, Jacobberger J, Exner AA, Lawes MC. Breast Cancer Res. 2019 Dec 5;21(1):138.
  12. A Metastable Contact and Structural Disorder in the Estrogen Receptor Transactivation Domain. Peng Y, Cao S, Kiselar J, Xiao X, Du Z, Hsieh A, Ko S, Chen Y, Agrawal P, Zheng W, Shi W, Jiang W, Yang L, Chance MR, Surewicz WK, Buck M, Yang S. Structure. 2019 Feb 5;27(2):229-240.e4.
  13. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Yang J, Liu Z, Wang C, Yang R, Rathkey JK, Pinkard OW, Shi W, Chen Y, Dubyak GR, Abbott DW, Xiao TS. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6792-6797.
  14. Phosphorylation of the E3 ubiquitin protein ligase ITCH diminishes binding to its cognate E2 ubiquitin ligase. Perez JM, Chen Y, Xiao TS, Abbott DW. J Biol Chem. 2018 Jan 19;293 (3):1100-1105.
  15. Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirieleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW. Sci Immunol. 2018 Aug 24;3(26):eaat2738.
  16. Non-catalytic signaling by pseudokinase ILK for regulating cell adhesion. Vaynberg J, Fukuda K, Lu F, Bialkowska K, Chen Y, Plow EF, Qin J. Nat Commun. 2018 Oct 26;9(1):4465.
  17. Multidomain architecture of estrogen receptor reveals interfacial cross-talk between its DNA-binding and ligand-binding domains. Huang W, Peng Y, Kiselar J, Zhao X, Albaqami A, Mendez D, Chen Y, Chakravarthy S, Gupta S, Ralston C, Kao HY, Chance MR, Yang S. Nat Commun. 2018 Aug 30;9(1):3520. doi: 10.1038/s41467-018-06034-2.
  18. EDB Fibronectin Specific Peptide for Prostate Cancer Targeting. Han Z, Zhou Z, Shi X, Wang J, Wu X, Sun D, Chen Y, Zhu H, Magi-Galluzzi C, Lu ZR. Bioconjug Chem. 2015 May 20;26(5):830-8
  19. Proposed docking interface between peptidoglycan and the target recognition domain of zoocin A. Chen Y, Simmonds RS, Timkovich R. Biochem Biophys Res Commun. 2013 Nov 15; 441 (2):297-300.
  20. Solution structure of the recombinant target recognition domain of zoocin A. Chen Y, Simmonds RS, Young JK, Timkovich R. Proteins. 2013 Apr;81(4):722-7.
  21. The metal binding site of zoocin A. Chen Y, Simmonds RS, Sloan GL, Timkovich R. J Biol Inorg Chem. 2008 Aug;13(6):855-60.
  22. Heme crevice disorder after sixth ligand displacement in the cytochrome c-551 family. Chen Y, Liang Q, Arciero DM, Hooper AB, Timkovich R. Arch Biochem Biophys. 2007 Jan 1;457(1):95-104.