The research in the Yang laboratory is focused on the structure, dynamics, and function of nuclear estrogen receptors (ER) regulating the development of early-stage breast cancers. Methods used in the lab include computational techniques (molecular dynamics simulation and residue-based structural modeling), experimental biophysical techniques (small-angle x-ray solution scattering or SAXS and labeling tools), and more importantly, their judicious combination. Our studies benefit from the excellent computing facilities and synchrotron sources to which we have access, and close links with other laboratories here at Cleveland and other parts of the nation.